DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections

Nucleic acid delivery: Instant, wide-ranging protection against influenza A and B A novel innoculation technique involving the injection of antibody-producing plasmid DNA has shown to be effective against influenza in mice. The flu is responsible for up to half a million deaths each year and up to f...

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Autores principales:	Sarah T. C. Elliott, Nicole L. Kallewaard, Ebony Benjamin, Leslie Wachter-Rosati, Josephine M. McAuliffe, Ami Patel, Trevor R. F. Smith, Katherine Schultheis, Daniel H. Park, Seleeke Flingai, Megan C. Wise, Janess Mendoza, Stephanie Ramos, Kate E. Broderick, Jian Yan, Laurent M. Humeau, Niranjan Y. Sardesai, Kar Muthumani, Qing Zhu, David B. Weiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/eacd8d537f1948d3bf6f77c99669bab8
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spelling	oai:doaj.org-article:eacd8d537f1948d3bf6f77c99669bab82021-12-02T12:30:10ZDMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections10.1038/s41541-017-0020-x2059-0105https://doaj.org/article/eacd8d537f1948d3bf6f77c99669bab82017-07-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0020-xhttps://doaj.org/toc/2059-0105Nucleic acid delivery: Instant, wide-ranging protection against influenza A and B A novel innoculation technique involving the injection of antibody-producing plasmid DNA has shown to be effective against influenza in mice. The flu is responsible for up to half a million deaths each year and up to five million cases of severe disease, while also posing a substantial pandemic threat, even with our current repertoire of vaccines. A team of researchers led by Sarah Elliott and David Weiner of The Wistar Institute of Anatomy and Biology, Philadelphia, developed potent plasmid-based constructs that, once injected, entered hosts’ cells and utilized cellular machinery to encode antibodies protective against a range of influenza A and B subtypes. DNA inoculation conferred acute protection from disease, with treated individuals also being immune to subsequent exposure. This approach warrants further investigation as an alternative technology for practical delivery of monoclonal antibody therapeutics.Sarah T. C. ElliottNicole L. KallewaardEbony BenjaminLeslie Wachter-RosatiJosephine M. McAuliffeAmi PatelTrevor R. F. SmithKatherine SchultheisDaniel H. ParkSeleeke FlingaiMegan C. WiseJaness MendozaStephanie RamosKate E. BroderickJian YanLaurent M. HumeauNiranjan Y. SardesaiKar MuthumaniQing ZhuDavid B. WeinerNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sarah T. C. Elliott Nicole L. Kallewaard Ebony Benjamin Leslie Wachter-Rosati Josephine M. McAuliffe Ami Patel Trevor R. F. Smith Katherine Schultheis Daniel H. Park Seleeke Flingai Megan C. Wise Janess Mendoza Stephanie Ramos Kate E. Broderick Jian Yan Laurent M. Humeau Niranjan Y. Sardesai Kar Muthumani Qing Zhu David B. Weiner DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
description	Nucleic acid delivery: Instant, wide-ranging protection against influenza A and B A novel innoculation technique involving the injection of antibody-producing plasmid DNA has shown to be effective against influenza in mice. The flu is responsible for up to half a million deaths each year and up to five million cases of severe disease, while also posing a substantial pandemic threat, even with our current repertoire of vaccines. A team of researchers led by Sarah Elliott and David Weiner of The Wistar Institute of Anatomy and Biology, Philadelphia, developed potent plasmid-based constructs that, once injected, entered hosts’ cells and utilized cellular machinery to encode antibodies protective against a range of influenza A and B subtypes. DNA inoculation conferred acute protection from disease, with treated individuals also being immune to subsequent exposure. This approach warrants further investigation as an alternative technology for practical delivery of monoclonal antibody therapeutics.
format	article
author	Sarah T. C. Elliott Nicole L. Kallewaard Ebony Benjamin Leslie Wachter-Rosati Josephine M. McAuliffe Ami Patel Trevor R. F. Smith Katherine Schultheis Daniel H. Park Seleeke Flingai Megan C. Wise Janess Mendoza Stephanie Ramos Kate E. Broderick Jian Yan Laurent M. Humeau Niranjan Y. Sardesai Kar Muthumani Qing Zhu David B. Weiner
author_facet	Sarah T. C. Elliott Nicole L. Kallewaard Ebony Benjamin Leslie Wachter-Rosati Josephine M. McAuliffe Ami Patel Trevor R. F. Smith Katherine Schultheis Daniel H. Park Seleeke Flingai Megan C. Wise Janess Mendoza Stephanie Ramos Kate E. Broderick Jian Yan Laurent M. Humeau Niranjan Y. Sardesai Kar Muthumani Qing Zhu David B. Weiner
author_sort	Sarah T. C. Elliott
title	DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
title_short	DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
title_full	DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
title_fullStr	DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
title_full_unstemmed	DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
title_sort	dmab inoculation of synthetic cross reactive antibodies protects against lethal influenza a and b infections
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eacd8d537f1948d3bf6f77c99669bab8
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DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections

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