RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi

Abstract The World Health Organization has selected Malawi as one of three sites to pilot the roll-out of RTS,S/AS01 in phase 4 trials. As policy discussions for the expanded use of RTS,S/AS01 continue, it will be critical to determine the performance of the vaccine according to seasonal patterns of...

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Autores principales:	Larry Han, Michael G. Hudgens, Michael E. Emch, Jonathan J. Juliano, Corinna Keeler, Francis Martinson, Portia Kamthunzi, Gerald Tegha, Marc Lievens, Irving F. Hoffman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eacfa2535bff46c195020640438a4bcb
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spelling	oai:doaj.org-article:eacfa2535bff46c195020640438a4bcb2021-12-02T16:07:46ZRTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi10.1038/s41598-017-07533-w2045-2322https://doaj.org/article/eacfa2535bff46c195020640438a4bcb2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07533-whttps://doaj.org/toc/2045-2322Abstract The World Health Organization has selected Malawi as one of three sites to pilot the roll-out of RTS,S/AS01 in phase 4 trials. As policy discussions for the expanded use of RTS,S/AS01 continue, it will be critical to determine the performance of the vaccine according to seasonal patterns of malaria transmission in regions of Africa. Given waning vaccine efficacy over time, this secondary analysis demonstrates that administering the vaccine to children in the months prior to malaria season could maximize impact of the vaccine. We followed children (5–17 months) and infants (6–12 weeks) assigned to one of three groups: (1) vaccine with four doses; (2) vaccine with three doses; (3) control. The primary endpoint was defined as episodes of clinical malaria. During the 4-years of follow-up, 658 of 1544 (42.6%) children and infants had at least one episode of clinical malaria. With each 1-inch increase in rainfall per month there was an associated increase in the rate of malaria by 12.6% (95% CI 9.6%, 15.6%, P < 0.0001) among children and 15.9% (95% CI 12.8%, 18.9%, P < 0.0001) among infants. There was no evidence of effect modification of vaccine efficacy by precipitation (89% power).Larry HanMichael G. HudgensMichael E. EmchJonathan J. JulianoCorinna KeelerFrancis MartinsonPortia KamthunziGerald TeghaMarc LievensIrving F. HoffmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Larry Han Michael G. Hudgens Michael E. Emch Jonathan J. Juliano Corinna Keeler Francis Martinson Portia Kamthunzi Gerald Tegha Marc Lievens Irving F. Hoffman RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi
description	Abstract The World Health Organization has selected Malawi as one of three sites to pilot the roll-out of RTS,S/AS01 in phase 4 trials. As policy discussions for the expanded use of RTS,S/AS01 continue, it will be critical to determine the performance of the vaccine according to seasonal patterns of malaria transmission in regions of Africa. Given waning vaccine efficacy over time, this secondary analysis demonstrates that administering the vaccine to children in the months prior to malaria season could maximize impact of the vaccine. We followed children (5–17 months) and infants (6–12 weeks) assigned to one of three groups: (1) vaccine with four doses; (2) vaccine with three doses; (3) control. The primary endpoint was defined as episodes of clinical malaria. During the 4-years of follow-up, 658 of 1544 (42.6%) children and infants had at least one episode of clinical malaria. With each 1-inch increase in rainfall per month there was an associated increase in the rate of malaria by 12.6% (95% CI 9.6%, 15.6%, P < 0.0001) among children and 15.9% (95% CI 12.8%, 18.9%, P < 0.0001) among infants. There was no evidence of effect modification of vaccine efficacy by precipitation (89% power).
format	article
author	Larry Han Michael G. Hudgens Michael E. Emch Jonathan J. Juliano Corinna Keeler Francis Martinson Portia Kamthunzi Gerald Tegha Marc Lievens Irving F. Hoffman
author_facet	Larry Han Michael G. Hudgens Michael E. Emch Jonathan J. Juliano Corinna Keeler Francis Martinson Portia Kamthunzi Gerald Tegha Marc Lievens Irving F. Hoffman
author_sort	Larry Han
title	RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi
title_short	RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi
title_full	RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi
title_fullStr	RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi
title_full_unstemmed	RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi
title_sort	rts,s/as01 malaria vaccine efficacy is not modified by seasonal precipitation: results from a phase 3 randomized controlled trial in malawi
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eacfa2535bff46c195020640438a4bcb
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RTS,S/AS01 Malaria Vaccine Efficacy is Not Modified by Seasonal Precipitation: Results from a Phase 3 Randomized Controlled Trial in Malawi

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