March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity

Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the primi...

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Autores principales:	Thiago J. Borges, Naoka Murakami, Felipe D. Machado, Ayesha Murshid, Benjamin J. Lang, Rafael L. Lopes, Laura M. Bellan, Mayuko Uehara, Krist H. Antunes, Maria José Pérez-Saéz, Gabriel Birrane, Priscila Vianna, João Ismael B. Gonçalves, Rafael F. Zanin, Jamil Azzi, Reza Abdi, Satoshi Ishido, Jeoung-Sook Shin, Ana Paula D. Souza, Stuart K. Calderwood, Leonardo V. Riella, Cristina Bonorino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ead005caa3954154a96d660f0fad15fc
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spelling	oai:doaj.org-article:ead005caa3954154a96d660f0fad15fc2021-12-02T16:56:59ZMarch1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity10.1038/s41467-018-05572-z2041-1723https://doaj.org/article/ead005caa3954154a96d660f0fad15fc2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05572-zhttps://doaj.org/toc/2041-1723Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the priming of alloimmunity and prolong graft survival in mouse models.Thiago J. BorgesNaoka MurakamiFelipe D. MachadoAyesha MurshidBenjamin J. LangRafael L. LopesLaura M. BellanMayuko UeharaKrist H. AntunesMaria José Pérez-SaézGabriel BirranePriscila ViannaJoão Ismael B. GonçalvesRafael F. ZaninJamil AzziReza AbdiSatoshi IshidoJeoung-Sook ShinAna Paula D. SouzaStuart K. CalderwoodLeonardo V. RiellaCristina BonorinoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thiago J. Borges Naoka Murakami Felipe D. Machado Ayesha Murshid Benjamin J. Lang Rafael L. Lopes Laura M. Bellan Mayuko Uehara Krist H. Antunes Maria José Pérez-Saéz Gabriel Birrane Priscila Vianna João Ismael B. Gonçalves Rafael F. Zanin Jamil Azzi Reza Abdi Satoshi Ishido Jeoung-Sook Shin Ana Paula D. Souza Stuart K. Calderwood Leonardo V. Riella Cristina Bonorino March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
description	Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the priming of alloimmunity and prolong graft survival in mouse models.
format	article
author	Thiago J. Borges Naoka Murakami Felipe D. Machado Ayesha Murshid Benjamin J. Lang Rafael L. Lopes Laura M. Bellan Mayuko Uehara Krist H. Antunes Maria José Pérez-Saéz Gabriel Birrane Priscila Vianna João Ismael B. Gonçalves Rafael F. Zanin Jamil Azzi Reza Abdi Satoshi Ishido Jeoung-Sook Shin Ana Paula D. Souza Stuart K. Calderwood Leonardo V. Riella Cristina Bonorino
author_facet	Thiago J. Borges Naoka Murakami Felipe D. Machado Ayesha Murshid Benjamin J. Lang Rafael L. Lopes Laura M. Bellan Mayuko Uehara Krist H. Antunes Maria José Pérez-Saéz Gabriel Birrane Priscila Vianna João Ismael B. Gonçalves Rafael F. Zanin Jamil Azzi Reza Abdi Satoshi Ishido Jeoung-Sook Shin Ana Paula D. Souza Stuart K. Calderwood Leonardo V. Riella Cristina Bonorino
author_sort	Thiago J. Borges
title	March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
title_short	March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
title_full	March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
title_fullStr	March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
title_full_unstemmed	March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
title_sort	march1-dependent modulation of donor mhc ii on cd103+ dendritic cells mitigates alloimmunity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ead005caa3954154a96d660f0fad15fc
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March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity

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