Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effective at killing M. ulcerans and is a promising th...
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/ead11814b4ee465d85398bdcb2064c81 |
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oai:doaj.org-article:ead11814b4ee465d85398bdcb2064c812021-12-02T17:31:14ZTargeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer10.1038/s41467-018-07804-82041-1723https://doaj.org/article/ead11814b4ee465d85398bdcb2064c812018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07804-8https://doaj.org/toc/2041-1723Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effective at killing M. ulcerans and is a promising therapeutic candidate for BU.Nicole ScherrRaphael BieriSangeeta S. ThomasAurélie ChauffourNitin Pal KaliaPaul SchneideMarie-Thérèse RufAraceli LamelasMalathy S. S. ManimekalaiGerhard GrüberNorihisa IshiiKoichi SuzukiMarcel TannerGarrett C. MoraskiMarvin J. MillerMatthias WitschelVincent JarlierGerd PluschkeKevin PetheNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nicole Scherr Raphael Bieri Sangeeta S. Thomas Aurélie Chauffour Nitin Pal Kalia Paul Schneide Marie-Thérèse Ruf Araceli Lamelas Malathy S. S. Manimekalai Gerhard Grüber Norihisa Ishii Koichi Suzuki Marcel Tanner Garrett C. Moraski Marvin J. Miller Matthias Witschel Vincent Jarlier Gerd Pluschke Kevin Pethe Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer |
| description |
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effective at killing M. ulcerans and is a promising therapeutic candidate for BU. |
| format |
article |
| author |
Nicole Scherr Raphael Bieri Sangeeta S. Thomas Aurélie Chauffour Nitin Pal Kalia Paul Schneide Marie-Thérèse Ruf Araceli Lamelas Malathy S. S. Manimekalai Gerhard Grüber Norihisa Ishii Koichi Suzuki Marcel Tanner Garrett C. Moraski Marvin J. Miller Matthias Witschel Vincent Jarlier Gerd Pluschke Kevin Pethe |
| author_facet |
Nicole Scherr Raphael Bieri Sangeeta S. Thomas Aurélie Chauffour Nitin Pal Kalia Paul Schneide Marie-Thérèse Ruf Araceli Lamelas Malathy S. S. Manimekalai Gerhard Grüber Norihisa Ishii Koichi Suzuki Marcel Tanner Garrett C. Moraski Marvin J. Miller Matthias Witschel Vincent Jarlier Gerd Pluschke Kevin Pethe |
| author_sort |
Nicole Scherr |
| title |
Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer |
| title_short |
Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer |
| title_full |
Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer |
| title_fullStr |
Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer |
| title_full_unstemmed |
Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer |
| title_sort |
targeting the mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of buruli ulcer |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ead11814b4ee465d85398bdcb2064c81 |
| work_keys_str_mv |
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| _version_ |
1718380707869360128 |