Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

The pathological form of prion protein (PrP(Sc)), as other amyloidogenic proteins, causes a marked increase of membrane permeability. PrP(Sc) extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, although the contribution of this interaction to th...

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Autores principales: Sacha Sorrentino, Tonino Bucciarelli, Alessandro Corsaro, Alessio Tosatto, Stefano Thellung, Valentina Villa, M Eugenia Schininà, Bruno Maras, Roberta Galeno, Luca Scotti, Francesco Creati, Alessandro Marrone, Nazzareno Re, Antonio Aceto, Tullio Florio, Michele Mazzanti
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ead178485c6b4a2694955f62460f34ad
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