Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging

Photoacoustic imaging (PAI) is a noninvasive biomedical imaging technology capable of multiscale imaging of biological samples from organs down to cells. Multiscale PAI requires different ultrasound transducers that are flat or focused because the current widely-used piezoelectric transducers are ri...

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Autores principales:	Bai-Ou Guan, Long Jin, Jun Ma, Yizhi Liang, Xue Bai
Formato:	article
Lenguaje:	EN
Publicado:	Institue of Optics and Electronics, Chinese Academy of Sciences 2021
Materias:	flexible ultrasound transducer fiber-laser ultrasound sensor multiscale photoacoustic imaging photoacoustic microscopy photoacoustic computed tomography Optics. Light QC350-467
Acceso en línea:	https://doaj.org/article/ead27c22d4ed49a983c80430690ac831
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id	oai:doaj.org-article:ead27c22d4ed49a983c80430690ac831
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spelling	oai:doaj.org-article:ead27c22d4ed49a983c80430690ac8312021-11-17T07:53:18ZFlexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging2096-457910.29026/oea.2021.200081https://doaj.org/article/ead27c22d4ed49a983c80430690ac8312021-08-01T00:00:00Zhttp://www.oejournal.org/article/doi/10.29026/oea.2021.200081https://doaj.org/toc/2096-4579Photoacoustic imaging (PAI) is a noninvasive biomedical imaging technology capable of multiscale imaging of biological samples from organs down to cells. Multiscale PAI requires different ultrasound transducers that are flat or focused because the current widely-used piezoelectric transducers are rigid and lack the flexibility to tune their spatial ultrasound responses. Inspired by the rapidly-developing flexible photonics, we exploited the inherent flexibility and low-loss features of optical fibers to develop a flexible fiber-laser ultrasound sensor (FUS) for multiscale PAI. By simply bending the fiber laser from straight to curved geometry, the spatial ultrasound response of the FUS can be tuned for both wide-view optical-resolution photoacoustic microscopy at optical diffraction-limited depth (~1 mm) and photoacoustic computed tomography at optical dissipation-limited depth of several centimeters. A radio-frequency demodulation was employed to get the readout of the beat frequency variation of two orthogonal polarization modes in the FUS output, which ensures low-noise and stable ultrasound detection. Compared to traditional piezoelectrical transducers with fixed ultrasound responses once manufactured, the flexible FUS provides the freedom to design multiscale PAI modalities including wearable microscope, intravascular endoscopy, and portable tomography system, which is attractive to fundamental biological/medical studies and clinical applications.Bai-Ou GuanLong JinJun MaYizhi LiangXue BaiInstitue of Optics and Electronics, Chinese Academy of Sciencesarticleflexible ultrasound transducerfiber-laser ultrasound sensormultiscale photoacoustic imagingphotoacoustic microscopyphotoacoustic computed tomographyOptics. LightQC350-467ENOpto-Electronic Advances, Vol 4, Iss 8, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flexible ultrasound transducer fiber-laser ultrasound sensor multiscale photoacoustic imaging photoacoustic microscopy photoacoustic computed tomography Optics. Light QC350-467
spellingShingle	flexible ultrasound transducer fiber-laser ultrasound sensor multiscale photoacoustic imaging photoacoustic microscopy photoacoustic computed tomography Optics. Light QC350-467 Bai-Ou Guan Long Jin Jun Ma Yizhi Liang Xue Bai Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging
description	Photoacoustic imaging (PAI) is a noninvasive biomedical imaging technology capable of multiscale imaging of biological samples from organs down to cells. Multiscale PAI requires different ultrasound transducers that are flat or focused because the current widely-used piezoelectric transducers are rigid and lack the flexibility to tune their spatial ultrasound responses. Inspired by the rapidly-developing flexible photonics, we exploited the inherent flexibility and low-loss features of optical fibers to develop a flexible fiber-laser ultrasound sensor (FUS) for multiscale PAI. By simply bending the fiber laser from straight to curved geometry, the spatial ultrasound response of the FUS can be tuned for both wide-view optical-resolution photoacoustic microscopy at optical diffraction-limited depth (~1 mm) and photoacoustic computed tomography at optical dissipation-limited depth of several centimeters. A radio-frequency demodulation was employed to get the readout of the beat frequency variation of two orthogonal polarization modes in the FUS output, which ensures low-noise and stable ultrasound detection. Compared to traditional piezoelectrical transducers with fixed ultrasound responses once manufactured, the flexible FUS provides the freedom to design multiscale PAI modalities including wearable microscope, intravascular endoscopy, and portable tomography system, which is attractive to fundamental biological/medical studies and clinical applications.
format	article
author	Bai-Ou Guan Long Jin Jun Ma Yizhi Liang Xue Bai
author_facet	Bai-Ou Guan Long Jin Jun Ma Yizhi Liang Xue Bai
author_sort	Bai-Ou Guan
title	Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging
title_short	Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging
title_full	Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging
title_fullStr	Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging
title_full_unstemmed	Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging
title_sort	flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging
publisher	Institue of Optics and Electronics, Chinese Academy of Sciences
publishDate	2021
url	https://doaj.org/article/ead27c22d4ed49a983c80430690ac831
work_keys_str_mv	AT baiouguan flexiblefiberlaserultrasoundsensorformultiscalephotoacousticimaging AT longjin flexiblefiberlaserultrasoundsensorformultiscalephotoacousticimaging AT junma flexiblefiberlaserultrasoundsensorformultiscalephotoacousticimaging AT yizhiliang flexiblefiberlaserultrasoundsensorformultiscalephotoacousticimaging AT xuebai flexiblefiberlaserultrasoundsensorformultiscalephotoacousticimaging
_version_	1718425896816214016

Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging

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