Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity

Background: Cisplatin is extensively used in treating cancers, and its primary side-effect is nephrotoxicity. It accumulates in proximal convoluted tubules where it promotes cellular damage by oxidative stress, apoptosis, and inflammation, etc. In Unani medicine, Tukhm-e-Karafs (Apium graveolens L.)...

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Autores principales:	Mohd Naushad, Mohd Urooj, Tasleem Ahmad, Gulam Mohammed Husain, Munawwar Husain Kazmi, Mohammad Zakir
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cisplatin KIM-1 Nephroprotective Nephrotoxicity Tukhm-e-Karafs Unani Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/ead554edfa144178894a1ec95e5c0091
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spelling	oai:doaj.org-article:ead554edfa144178894a1ec95e5c00912021-12-02T04:59:19ZNephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity0975-947610.1016/j.jaim.2021.06.005https://doaj.org/article/ead554edfa144178894a1ec95e5c00912021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0975947621001133https://doaj.org/toc/0975-9476Background: Cisplatin is extensively used in treating cancers, and its primary side-effect is nephrotoxicity. It accumulates in proximal convoluted tubules where it promotes cellular damage by oxidative stress, apoptosis, and inflammation, etc. In Unani medicine, Tukhm-e-Karafs (Apium graveolens L.) (TK) is mentioned in the literature to manage various kidney ailments due to its diuretic and deobstruent activities. Objective: To investigate the nephroprotective effects of powder of TK in Cisplatin-induced nephrotoxicity in an animal model and to validate the Unani claim of its nephroprotective action. Material and methods: In curative protocol, cisplatin (5 mg/kg body weight i.p) was administered on day one and powder of TK (500 and 1000 mg/kg p.o.) from the sixth day onwards for ten days. TK (500 and 1000 mg/kg p.o.) was given for ten days and Cisplatin (5 mg/kg body weight i.p) on day 11 in the protective model. At the end of the study, all the animals were sacrificed, and renal biochemical parameters were determined. KIM-1 level was also investigated in the kidney homogenate in conjunction with histopathological inspection of kidney tissues. Results: Significant increase in serum creatinine and BUN, presence of mononuclear cell infiltration, tubular dilation and vacuolation in renal histopathology, and increased KIM-1 level confirmed the nephrotoxicity due to Cisplatin. TK's administration protects the kidney as suggested by the changes in biochemical renal function, decreased level of KIM-1, and improvement in histopathological changes. Conclusion: The result advocated that TK prevented renal injury and maintained normal renal function in both models. It may be due to improved clearance of Cisplatin from kidney tubules and reduction in reactive oxygen species (ROS) produced by the inflammatory response.Mohd NaushadMohd UroojTasleem AhmadGulam Mohammed HusainMunawwar Husain KazmiMohammad ZakirElsevierarticleCisplatinKIM-1NephroprotectiveNephrotoxicityTukhm-e-KarafsUnaniMiscellaneous systems and treatmentsRZ409.7-999ENJournal of Ayurveda and Integrative Medicine, Vol 12, Iss 4, Pp 607-615 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cisplatin KIM-1 Nephroprotective Nephrotoxicity Tukhm-e-Karafs Unani Miscellaneous systems and treatments RZ409.7-999
spellingShingle	Cisplatin KIM-1 Nephroprotective Nephrotoxicity Tukhm-e-Karafs Unani Miscellaneous systems and treatments RZ409.7-999 Mohd Naushad Mohd Urooj Tasleem Ahmad Gulam Mohammed Husain Munawwar Husain Kazmi Mohammad Zakir Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity
description	Background: Cisplatin is extensively used in treating cancers, and its primary side-effect is nephrotoxicity. It accumulates in proximal convoluted tubules where it promotes cellular damage by oxidative stress, apoptosis, and inflammation, etc. In Unani medicine, Tukhm-e-Karafs (Apium graveolens L.) (TK) is mentioned in the literature to manage various kidney ailments due to its diuretic and deobstruent activities. Objective: To investigate the nephroprotective effects of powder of TK in Cisplatin-induced nephrotoxicity in an animal model and to validate the Unani claim of its nephroprotective action. Material and methods: In curative protocol, cisplatin (5 mg/kg body weight i.p) was administered on day one and powder of TK (500 and 1000 mg/kg p.o.) from the sixth day onwards for ten days. TK (500 and 1000 mg/kg p.o.) was given for ten days and Cisplatin (5 mg/kg body weight i.p) on day 11 in the protective model. At the end of the study, all the animals were sacrificed, and renal biochemical parameters were determined. KIM-1 level was also investigated in the kidney homogenate in conjunction with histopathological inspection of kidney tissues. Results: Significant increase in serum creatinine and BUN, presence of mononuclear cell infiltration, tubular dilation and vacuolation in renal histopathology, and increased KIM-1 level confirmed the nephrotoxicity due to Cisplatin. TK's administration protects the kidney as suggested by the changes in biochemical renal function, decreased level of KIM-1, and improvement in histopathological changes. Conclusion: The result advocated that TK prevented renal injury and maintained normal renal function in both models. It may be due to improved clearance of Cisplatin from kidney tubules and reduction in reactive oxygen species (ROS) produced by the inflammatory response.
format	article
author	Mohd Naushad Mohd Urooj Tasleem Ahmad Gulam Mohammed Husain Munawwar Husain Kazmi Mohammad Zakir
author_facet	Mohd Naushad Mohd Urooj Tasleem Ahmad Gulam Mohammed Husain Munawwar Husain Kazmi Mohammad Zakir
author_sort	Mohd Naushad
title	Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity
title_short	Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity
title_full	Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity
title_fullStr	Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity
title_full_unstemmed	Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity
title_sort	nephroprotective effect of apium graveolens l. against cisplatin-induced nephrotoxicity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ead554edfa144178894a1ec95e5c0091
work_keys_str_mv	AT mohdnaushad nephroprotectiveeffectofapiumgraveolenslagainstcisplatininducednephrotoxicity AT mohdurooj nephroprotectiveeffectofapiumgraveolenslagainstcisplatininducednephrotoxicity AT tasleemahmad nephroprotectiveeffectofapiumgraveolenslagainstcisplatininducednephrotoxicity AT gulammohammedhusain nephroprotectiveeffectofapiumgraveolenslagainstcisplatininducednephrotoxicity AT munawwarhusainkazmi nephroprotectiveeffectofapiumgraveolenslagainstcisplatininducednephrotoxicity AT mohammadzakir nephroprotectiveeffectofapiumgraveolenslagainstcisplatininducednephrotoxicity
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Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity

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