Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins and increased virulence.

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Autores principales:	Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, Holly A. Laakso, Nancy C. Friedrich, Julienne C. Kaiser, David W. Watson, Christy H. Wilson, Jessica R. Sheldon, Martin J. McGavin, Patti K. Kiser, David E. Heinrichs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ead5d2b62f80403bb70afcb3ba0ddcd8
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spelling	oai:doaj.org-article:ead5d2b62f80403bb70afcb3ba0ddcd82021-12-02T17:01:47ZStress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence10.1038/s41467-019-08724-x2041-1723https://doaj.org/article/ead5d2b62f80403bb70afcb3ba0ddcd82019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08724-xhttps://doaj.org/toc/2041-1723PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins and increased virulence.Mariya I. GonchevaRonald S. FlannaganBrigid E. SterlingHolly A. LaaksoNancy C. FriedrichJulienne C. KaiserDavid W. WatsonChristy H. WilsonJessica R. SheldonMartin J. McGavinPatti K. KiserDavid E. HeinrichsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariya I. Goncheva Ronald S. Flannagan Brigid E. Sterling Holly A. Laakso Nancy C. Friedrich Julienne C. Kaiser David W. Watson Christy H. Wilson Jessica R. Sheldon Martin J. McGavin Patti K. Kiser David E. Heinrichs Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
description	PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins and increased virulence.
format	article
author	Mariya I. Goncheva Ronald S. Flannagan Brigid E. Sterling Holly A. Laakso Nancy C. Friedrich Julienne C. Kaiser David W. Watson Christy H. Wilson Jessica R. Sheldon Martin J. McGavin Patti K. Kiser David E. Heinrichs
author_facet	Mariya I. Goncheva Ronald S. Flannagan Brigid E. Sterling Holly A. Laakso Nancy C. Friedrich Julienne C. Kaiser David W. Watson Christy H. Wilson Jessica R. Sheldon Martin J. McGavin Patti K. Kiser David E. Heinrichs
author_sort	Mariya I. Goncheva
title	Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
title_short	Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
title_full	Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
title_fullStr	Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
title_full_unstemmed	Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
title_sort	stress-induced inactivation of the staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ead5d2b62f80403bb70afcb3ba0ddcd8
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Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

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