Genetic susceptibility to non-necrotizing erysipelas/cellulitis.

<h4>Background</h4>Bacterial non-necrotizing erysipelas and cellulitis are often recurring, diffusely spreading infections of the skin and subcutaneous tissues caused most commonly by streptococci. Host genetic factors influence infection susceptibility but no extensive studies on the ge...

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Autores principales:	Katariina Hannula-Jouppi, Satu Massinen, Tuula Siljander, Siru Mäkelä, Katja Kivinen, Rasko Leinonen, Hong Jiao, Päivi Aitos, Matti Karppelin, Jaana Vuopio, Jaana Syrjänen, Juha Kere
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ead72d7e0cbf46989e37a6c0af14e37a
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spelling	oai:doaj.org-article:ead72d7e0cbf46989e37a6c0af14e37a2021-11-18T07:56:57ZGenetic susceptibility to non-necrotizing erysipelas/cellulitis.1932-620310.1371/journal.pone.0056225https://doaj.org/article/ead72d7e0cbf46989e37a6c0af14e37a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23437094/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Bacterial non-necrotizing erysipelas and cellulitis are often recurring, diffusely spreading infections of the skin and subcutaneous tissues caused most commonly by streptococci. Host genetic factors influence infection susceptibility but no extensive studies on the genetic determinants of human erysipelas exist.<h4>Methods</h4>We performed genome-wide linkage with the 10,000 variant Human Mapping Array (HMA10K) array on 52 Finnish families with multiple erysipelas cases followed by microsatellite fine mapping of suggestive linkage peaks. A scan with the HMA250K array was subsequently performed with a subset of cases and controls.<h4>Results</h4>Significant linkage was found at 9q34 (nonparametric multipoint linkage score (NPL(all)) 3.84, p=0.026), which is syntenic to a quantitative trait locus for susceptibility to group A streptococci infections on chromosome 2 in mouse. Sequencing of candidate genes in the 9q34 region did not conclusively associate any to erysipelas/cellulitis susceptibility. Suggestive linkage (NPL(all)>3.0) was found at three loci: 3q22-24, 21q22, and 22q13. A subsequent denser genome scan with the HMA250K array supported the 3q22 locus, in which several SNPs in the promoter of AGTR1 (Angiotensin II receptor type I) suggestively associated with erysipelas/cellulitis susceptibility.<h4>Conclusions</h4>Specific host genetic factors may cause erysipelas/cellulitis susceptibility in humans.Katariina Hannula-JouppiSatu MassinenTuula SiljanderSiru MäkeläKatja KivinenRasko LeinonenHong JiaoPäivi AitosMatti KarppelinJaana VuopioJaana SyrjänenJuha KerePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56225 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katariina Hannula-Jouppi Satu Massinen Tuula Siljander Siru Mäkelä Katja Kivinen Rasko Leinonen Hong Jiao Päivi Aitos Matti Karppelin Jaana Vuopio Jaana Syrjänen Juha Kere Genetic susceptibility to non-necrotizing erysipelas/cellulitis.
description	<h4>Background</h4>Bacterial non-necrotizing erysipelas and cellulitis are often recurring, diffusely spreading infections of the skin and subcutaneous tissues caused most commonly by streptococci. Host genetic factors influence infection susceptibility but no extensive studies on the genetic determinants of human erysipelas exist.<h4>Methods</h4>We performed genome-wide linkage with the 10,000 variant Human Mapping Array (HMA10K) array on 52 Finnish families with multiple erysipelas cases followed by microsatellite fine mapping of suggestive linkage peaks. A scan with the HMA250K array was subsequently performed with a subset of cases and controls.<h4>Results</h4>Significant linkage was found at 9q34 (nonparametric multipoint linkage score (NPL(all)) 3.84, p=0.026), which is syntenic to a quantitative trait locus for susceptibility to group A streptococci infections on chromosome 2 in mouse. Sequencing of candidate genes in the 9q34 region did not conclusively associate any to erysipelas/cellulitis susceptibility. Suggestive linkage (NPL(all)>3.0) was found at three loci: 3q22-24, 21q22, and 22q13. A subsequent denser genome scan with the HMA250K array supported the 3q22 locus, in which several SNPs in the promoter of AGTR1 (Angiotensin II receptor type I) suggestively associated with erysipelas/cellulitis susceptibility.<h4>Conclusions</h4>Specific host genetic factors may cause erysipelas/cellulitis susceptibility in humans.
format	article
author	Katariina Hannula-Jouppi Satu Massinen Tuula Siljander Siru Mäkelä Katja Kivinen Rasko Leinonen Hong Jiao Päivi Aitos Matti Karppelin Jaana Vuopio Jaana Syrjänen Juha Kere
author_facet	Katariina Hannula-Jouppi Satu Massinen Tuula Siljander Siru Mäkelä Katja Kivinen Rasko Leinonen Hong Jiao Päivi Aitos Matti Karppelin Jaana Vuopio Jaana Syrjänen Juha Kere
author_sort	Katariina Hannula-Jouppi
title	Genetic susceptibility to non-necrotizing erysipelas/cellulitis.
title_short	Genetic susceptibility to non-necrotizing erysipelas/cellulitis.
title_full	Genetic susceptibility to non-necrotizing erysipelas/cellulitis.
title_fullStr	Genetic susceptibility to non-necrotizing erysipelas/cellulitis.
title_full_unstemmed	Genetic susceptibility to non-necrotizing erysipelas/cellulitis.
title_sort	genetic susceptibility to non-necrotizing erysipelas/cellulitis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ead72d7e0cbf46989e37a6c0af14e37a
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Genetic susceptibility to non-necrotizing erysipelas/cellulitis.

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