Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors
Yunfei Niu,1,* Wei Dong,1,* Han Guo,2 Yuhu Deng,3 Lieping Guo,1 Xiaofei An,1 Dawei He,1 Jie Wei,3 Ming Li11Department of Orthopedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Shanghai Synchrotron Radiation Facility, Shanghai Instit...
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Dove Medical Press
2014
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oai:doaj.org-article:ead76c5faa614462b9c28f985b6778612021-12-02T01:11:29ZMesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors1178-2013https://doaj.org/article/ead76c5faa614462b9c28f985b6778612014-05-01T00:00:00Zhttp://www.dovepress.com/mesoporous-magnesium-silicate-incorporated-polyepsilon-caprolactone-po-a17009https://doaj.org/toc/1178-2013 Yunfei Niu,1,* Wei Dong,1,* Han Guo,2 Yuhu Deng,3 Lieping Guo,1 Xiaofei An,1 Dawei He,1 Jie Wei,3 Ming Li11Department of Orthopedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China *These authors contributed equally to this workAbstract: Mesoporous magnesium silicate (m-MS) and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength and elastic modulus, as well as hydrophilicity, of the m-MPC increased with increase of m-MS content in the composites. In addition, the weight loss of the m-MPC improved significantly with the increase of m-MS content during composite soaking in phosphate-buffered saline for 10 weeks, indicating that incorporation of m-MS into PCL-PEG-PCL could enhance the degradability of the m-MPC. Moreover, the m-MPC with 40 w% m-MS could induce a dense and continuous apatite layer on its surface after soaking in simulated body fluid for 5 days, which was better than m-MPC 20 w% m-MS, exhibiting excellent in vitro bioactivity. In cell cultural experiments, the results showed that the attachment and viability ratio of MG63 cells on m-MPC increased significantly with the increase of m-MS content, showing that the addition of m-MS into PCL-PEG-PCL could promote cell attachment and proliferation. The results suggest that the incorporation of m-MS into PCL-PEG-PCL could produce bioactive composites with improved hydrophilicity, degradability, bioactivity, and cytocompatibility.Keywords: PCL-PEG-PCL, degradation, cytocompatibility, cell attachment, cell proliferationNiu YDong WGuo HDeng YGuo LAn XHe DWei JLi MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2665-2675 (2014) |
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Medicine (General) R5-920 Niu Y Dong W Guo H Deng Y Guo L An X He D Wei J Li M Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors |
| description |
Yunfei Niu,1,* Wei Dong,1,* Han Guo,2 Yuhu Deng,3 Lieping Guo,1 Xiaofei An,1 Dawei He,1 Jie Wei,3 Ming Li11Department of Orthopedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China *These authors contributed equally to this workAbstract: Mesoporous magnesium silicate (m-MS) and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength and elastic modulus, as well as hydrophilicity, of the m-MPC increased with increase of m-MS content in the composites. In addition, the weight loss of the m-MPC improved significantly with the increase of m-MS content during composite soaking in phosphate-buffered saline for 10 weeks, indicating that incorporation of m-MS into PCL-PEG-PCL could enhance the degradability of the m-MPC. Moreover, the m-MPC with 40 w% m-MS could induce a dense and continuous apatite layer on its surface after soaking in simulated body fluid for 5 days, which was better than m-MPC 20 w% m-MS, exhibiting excellent in vitro bioactivity. In cell cultural experiments, the results showed that the attachment and viability ratio of MG63 cells on m-MPC increased significantly with the increase of m-MS content, showing that the addition of m-MS into PCL-PEG-PCL could promote cell attachment and proliferation. The results suggest that the incorporation of m-MS into PCL-PEG-PCL could produce bioactive composites with improved hydrophilicity, degradability, bioactivity, and cytocompatibility.Keywords: PCL-PEG-PCL, degradation, cytocompatibility, cell attachment, cell proliferation |
| format |
article |
| author |
Niu Y Dong W Guo H Deng Y Guo L An X He D Wei J Li M |
| author_facet |
Niu Y Dong W Guo H Deng Y Guo L An X He D Wei J Li M |
| author_sort |
Niu Y |
| title |
Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors |
| title_short |
Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors |
| title_full |
Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors |
| title_fullStr |
Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors |
| title_full_unstemmed |
Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors |
| title_sort |
mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/ead76c5faa614462b9c28f985b677861 |
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