Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses

Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scor...

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Autores principales:	Fei Xiao, Denian Wang, Lingmiao Kong, Min Li, Zhongxue Feng, Bingxing Shuai, Lijun Wang, Yong’gang Wei, Hongyu Li, Sisi Wu, Chun Tan, Huan Zhao, Xuejiao Hu, Jin Liu, Yan Kang, Xuelian Liao, Yan Zhou, Wei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ead986329bea46afb1f74f0ac772d550
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spelling	oai:doaj.org-article:ead986329bea46afb1f74f0ac772d5502021-12-02T17:31:46ZIntermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses10.1038/s41467-018-05062-22041-1723https://doaj.org/article/ead986329bea46afb1f74f0ac772d5502018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05062-2https://doaj.org/toc/2041-1723Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes.Fei XiaoDenian WangLingmiao KongMin LiZhongxue FengBingxing ShuaiLijun WangYong’gang WeiHongyu LiSisi WuChun TanHuan ZhaoXuejiao HuJin LiuYan KangXuelian LiaoYan ZhouWei ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fei Xiao Denian Wang Lingmiao Kong Min Li Zhongxue Feng Bingxing Shuai Lijun Wang Yong’gang Wei Hongyu Li Sisi Wu Chun Tan Huan Zhao Xuejiao Hu Jin Liu Yan Kang Xuelian Liao Yan Zhou Wei Zhang Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
description	Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes.
format	article
author	Fei Xiao Denian Wang Lingmiao Kong Min Li Zhongxue Feng Bingxing Shuai Lijun Wang Yong’gang Wei Hongyu Li Sisi Wu Chun Tan Huan Zhao Xuejiao Hu Jin Liu Yan Kang Xuelian Liao Yan Zhou Wei Zhang
author_facet	Fei Xiao Denian Wang Lingmiao Kong Min Li Zhongxue Feng Bingxing Shuai Lijun Wang Yong’gang Wei Hongyu Li Sisi Wu Chun Tan Huan Zhao Xuejiao Hu Jin Liu Yan Kang Xuelian Liao Yan Zhou Wei Zhang
author_sort	Fei Xiao
title	Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
title_short	Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
title_full	Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
title_fullStr	Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
title_full_unstemmed	Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
title_sort	intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ead986329bea46afb1f74f0ac772d550
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Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses

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