Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping

Abstract Previous studies suggested that genetic, environmental factors and their interactions could affect body fat mass (BFM). However, studies describing these effects were performed at a single time point in a population. In this study, we investigated the interaction between genetic and environ...

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Autores principales:	Joon Ho Kang, Heewon Kim, Jinki Kim, Jong-Hwa Seo, Soyeon Cha, Hyunjung Oh, Kyunga Kim, Seong-Jin Park, Eunbin Kim, Sunga Kong, Jae-Hak Lee, Joon Seol Bae, Hong-Hee Won, Je-Gun Joung, Yoon Jung Yang, Jinho Kim, Woong-Yang Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eae3c884d01446a0a19bbc0f516945fa
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spelling	oai:doaj.org-article:eae3c884d01446a0a19bbc0f516945fa2021-12-02T17:12:21ZInteraction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping10.1038/s41598-021-92229-52045-2322https://doaj.org/article/eae3c884d01446a0a19bbc0f516945fa2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92229-5https://doaj.org/toc/2045-2322Abstract Previous studies suggested that genetic, environmental factors and their interactions could affect body fat mass (BFM). However, studies describing these effects were performed at a single time point in a population. In this study, we investigated the interaction between genetic and environmental factors in affecting BFM and implicate the healthcare utilization of lifestyle modifications from a personalized and genomic perspective. We examined how nutritional intake or physical activity changes in the individuals affect BFM concerning the genetic composition. We conducted an observational study including 259 adult participants with single nucleotide polymorphism (SNP) genotyping and longitudinal lifestyle monitoring, including food consumption and physical activities, by following lifestyle modification guidance. The participants’ lifelog data on exercise and diet were collected through a wearable device for 3 months. Moreover, we measured anthropometric and serologic markers to monitor their potential changes through lifestyle modification. We examined the influence of genetic composition on body fat reduction induced by lifestyle changes using genetic risk scores (GRSs) of three phenotypes: GRS-carbohydrate (GRS-C), GRS-fat (GRS-F), and GRS-exercise (GRS-E). Our results showed that lifestyle modifications affected BFM more significantly in the high GRS class compared to the low GRS class, indicating the role of genetic factors affecting the efficiency of the lifestyle modification-induced BFM changes. Interestingly, the influence of exercise modification in the low GRS class with active lifestyle change was lower than that in the high GRS class with inactive lifestyle change (P = 0.022), suggesting the implication of genetic factors for efficient body fat control.Joon Ho KangHeewon KimJinki KimJong-Hwa SeoSoyeon ChaHyunjung OhKyunga KimSeong-Jin ParkEunbin KimSunga KongJae-Hak LeeJoon Seol BaeHong-Hee WonJe-Gun JoungYoon Jung YangJinho KimWoong-Yang ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joon Ho Kang Heewon Kim Jinki Kim Jong-Hwa Seo Soyeon Cha Hyunjung Oh Kyunga Kim Seong-Jin Park Eunbin Kim Sunga Kong Jae-Hak Lee Joon Seol Bae Hong-Hee Won Je-Gun Joung Yoon Jung Yang Jinho Kim Woong-Yang Park Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping
description	Abstract Previous studies suggested that genetic, environmental factors and their interactions could affect body fat mass (BFM). However, studies describing these effects were performed at a single time point in a population. In this study, we investigated the interaction between genetic and environmental factors in affecting BFM and implicate the healthcare utilization of lifestyle modifications from a personalized and genomic perspective. We examined how nutritional intake or physical activity changes in the individuals affect BFM concerning the genetic composition. We conducted an observational study including 259 adult participants with single nucleotide polymorphism (SNP) genotyping and longitudinal lifestyle monitoring, including food consumption and physical activities, by following lifestyle modification guidance. The participants’ lifelog data on exercise and diet were collected through a wearable device for 3 months. Moreover, we measured anthropometric and serologic markers to monitor their potential changes through lifestyle modification. We examined the influence of genetic composition on body fat reduction induced by lifestyle changes using genetic risk scores (GRSs) of three phenotypes: GRS-carbohydrate (GRS-C), GRS-fat (GRS-F), and GRS-exercise (GRS-E). Our results showed that lifestyle modifications affected BFM more significantly in the high GRS class compared to the low GRS class, indicating the role of genetic factors affecting the efficiency of the lifestyle modification-induced BFM changes. Interestingly, the influence of exercise modification in the low GRS class with active lifestyle change was lower than that in the high GRS class with inactive lifestyle change (P = 0.022), suggesting the implication of genetic factors for efficient body fat control.
format	article
author	Joon Ho Kang Heewon Kim Jinki Kim Jong-Hwa Seo Soyeon Cha Hyunjung Oh Kyunga Kim Seong-Jin Park Eunbin Kim Sunga Kong Jae-Hak Lee Joon Seol Bae Hong-Hee Won Je-Gun Joung Yoon Jung Yang Jinho Kim Woong-Yang Park
author_facet	Joon Ho Kang Heewon Kim Jinki Kim Jong-Hwa Seo Soyeon Cha Hyunjung Oh Kyunga Kim Seong-Jin Park Eunbin Kim Sunga Kong Jae-Hak Lee Joon Seol Bae Hong-Hee Won Je-Gun Joung Yoon Jung Yang Jinho Kim Woong-Yang Park
author_sort	Joon Ho Kang
title	Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping
title_short	Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping
title_full	Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping
title_fullStr	Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping
title_full_unstemmed	Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping
title_sort	interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eae3c884d01446a0a19bbc0f516945fa
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Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping

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