Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency

Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency

Abstract Arginase-1 deficiency in humans is a rare genetic disorder of metabolism resulting from a loss of arginase-1, leading to impaired ureagenesis, hyperargininemia and neurological deficits. Previously, we generated a tamoxifen-inducible arginase-1 deficient mouse model harboring a deletion of...

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Autores principales: Yuan Yan Sin, Phillipe R. Price, Laurel L. Ballantyne, Colin D. Funk
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/eae6a3ed458b46789cceae268bf9e7a9
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