Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats

High-fat diet (HFD) could induce obese and microbial dysbiosis, the latter of which has great impact on host health. Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health. In this study, we investigated the effects of rapeseed polysaccharide (RSP) on ove...

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Autores principales:	Chen Yang, Xu Wang, Qianchun Deng, Fenghong Huang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Gut microbiota Rapeseed polysaccharides Overweight and obese High-fat diet Genetics QH426-470
Acceso en línea:	https://doaj.org/article/eae74a311c01495dbf12344cb01a3306
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spelling	oai:doaj.org-article:eae74a311c01495dbf12344cb01a33062021-11-26T04:27:32ZRapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats2096-242810.1016/j.ocsci.2021.09.001https://doaj.org/article/eae74a311c01495dbf12344cb01a33062021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S209624282100049Xhttps://doaj.org/toc/2096-2428High-fat diet (HFD) could induce obese and microbial dysbiosis, the latter of which has great impact on host health. Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health. In this study, we investigated the effects of rapeseed polysaccharide (RSP) on overweight and gut microbiota in high-fat-diet (HFD) fed rats. RSP effectively alleviated the hyperglycemia and lipid metabolic disorder in serum, which was found closely related to the modulation of intestinal microbiota. Supplementation of RSP regulated the intestinal microbiome by increasing the proportion of butyrate acid producer Blautia (P < 0.05), Dorea (P < 0.01) and Akkermansia genus and inhibiting the growth of bacterial species associated with inflammation such as unclassified Ruminococcaceae (P < 0.05). Moreover, the restoration of total short-chain fatty acids (SCFAs), especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders. Our results suggested that RSP is a potential prebiotic for preventing obese induced HFD through regulating the gut microbiota.Chen YangXu WangQianchun DengFenghong HuangKeAi Communications Co., Ltd.articleGut microbiotaRapeseed polysaccharidesOverweight and obeseHigh-fat dietGeneticsQH426-470ENOil Crop Science, Vol 6, Iss 4, Pp 192-200 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gut microbiota Rapeseed polysaccharides Overweight and obese High-fat diet Genetics QH426-470
spellingShingle	Gut microbiota Rapeseed polysaccharides Overweight and obese High-fat diet Genetics QH426-470 Chen Yang Xu Wang Qianchun Deng Fenghong Huang Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats
description	High-fat diet (HFD) could induce obese and microbial dysbiosis, the latter of which has great impact on host health. Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health. In this study, we investigated the effects of rapeseed polysaccharide (RSP) on overweight and gut microbiota in high-fat-diet (HFD) fed rats. RSP effectively alleviated the hyperglycemia and lipid metabolic disorder in serum, which was found closely related to the modulation of intestinal microbiota. Supplementation of RSP regulated the intestinal microbiome by increasing the proportion of butyrate acid producer Blautia (P < 0.05), Dorea (P < 0.01) and Akkermansia genus and inhibiting the growth of bacterial species associated with inflammation such as unclassified Ruminococcaceae (P < 0.05). Moreover, the restoration of total short-chain fatty acids (SCFAs), especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders. Our results suggested that RSP is a potential prebiotic for preventing obese induced HFD through regulating the gut microbiota.
format	article
author	Chen Yang Xu Wang Qianchun Deng Fenghong Huang
author_facet	Chen Yang Xu Wang Qianchun Deng Fenghong Huang
author_sort	Chen Yang
title	Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats
title_short	Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats
title_full	Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats
title_fullStr	Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats
title_full_unstemmed	Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats
title_sort	rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/eae74a311c01495dbf12344cb01a3306
work_keys_str_mv	AT chenyang rapeseedpolysaccharidesalleviateoverweightinducedbyhighfatdietwithregulationofgutmicrobiotainrats AT xuwang rapeseedpolysaccharidesalleviateoverweightinducedbyhighfatdietwithregulationofgutmicrobiotainrats AT qianchundeng rapeseedpolysaccharidesalleviateoverweightinducedbyhighfatdietwithregulationofgutmicrobiotainrats AT fenghonghuang rapeseedpolysaccharidesalleviateoverweightinducedbyhighfatdietwithregulationofgutmicrobiotainrats
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Rapeseed polysaccharides alleviate overweight induced by high-fat diet with regulation of gut microbiota in rats

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