Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.

<h4>Objectives</h4>To assess the distribution of bone erosions and two erosion scores in the feet of patients with gout and analyze the association between erosion scores and monosodium urate (MSU) crystal deposition using dual-energy computed tomography (DECT).<h4>Materials and me...

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Autores principales:	Amandine Chabernaud Negrier, Lokmane Taihi, Eric Vicaut, Pascal Richette, Thomas Bardin, Frédéric Lioté, Hang-Korng Ea, Valérie Bousson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eaea0989959d4b6ab5dd5739064c865b
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spelling	oai:doaj.org-article:eaea0989959d4b6ab5dd5739064c865b2021-12-02T20:04:33ZDistribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.1932-620310.1371/journal.pone.0259194https://doaj.org/article/eaea0989959d4b6ab5dd5739064c865b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259194https://doaj.org/toc/1932-6203<h4>Objectives</h4>To assess the distribution of bone erosions and two erosion scores in the feet of patients with gout and analyze the association between erosion scores and monosodium urate (MSU) crystal deposition using dual-energy computed tomography (DECT).<h4>Materials and methods</h4>We included all patients who underwent DECT of both feet between 2016 and 2019 in our radiology department, with positive detection of MSU deposits. Data on sex, age, treatment, serum urate, and DECT urate volumes were obtained. CT images were analyzed to score bone erosions in 31 sites per foot by using the semi-quantitative method based on the Rheumatoid Arthritis MRI Scoring (RAMRIS) system and the Dalbeth-simplified score. Reproducibility for the two scores was calculated with intraclass correlation coefficients (ICCs). Correlations between clinical features, erosion scores and urate crystal volume were analyzed by the Spearman correlation coefficient (r).<h4>Results</h4>We studied 61 patients (mean age 62.0 years); 3,751 bones were scored. The first metatarsophalangeal joint and the midfoot were the most involved in terms of frequency and severity of bone erosions. The distribution of bone erosions was not asymmetrical. The intra- and inter-observer reproducibility was similar for the RAMRIS and Dalbeth-simplified scores (ICC 0.93 vs 0.94 and 0.96 vs 0.90). DECT urate volume was significantly correlated with each of the two erosion scores (r = 0.58-0.63, p < 0.001). There was a high correlation between the two scores (r = 0.96, p < 0.001).<h4>Conclusions</h4>DECT demonstrates that foot erosions are not asymmetric in distribution and predominate at the first ray and midfoot. The two erosion scores are significantly correlated with DECT urate volume. An almost perfect correlation between the RAMRIS and Dalbeth-simplified scores is observed.Amandine Chabernaud NegrierLokmane TaihiEric VicautPascal RichetteThomas BardinFrédéric LiotéHang-Korng EaValérie BoussonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259194 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amandine Chabernaud Negrier Lokmane Taihi Eric Vicaut Pascal Richette Thomas Bardin Frédéric Lioté Hang-Korng Ea Valérie Bousson Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.
description	<h4>Objectives</h4>To assess the distribution of bone erosions and two erosion scores in the feet of patients with gout and analyze the association between erosion scores and monosodium urate (MSU) crystal deposition using dual-energy computed tomography (DECT).<h4>Materials and methods</h4>We included all patients who underwent DECT of both feet between 2016 and 2019 in our radiology department, with positive detection of MSU deposits. Data on sex, age, treatment, serum urate, and DECT urate volumes were obtained. CT images were analyzed to score bone erosions in 31 sites per foot by using the semi-quantitative method based on the Rheumatoid Arthritis MRI Scoring (RAMRIS) system and the Dalbeth-simplified score. Reproducibility for the two scores was calculated with intraclass correlation coefficients (ICCs). Correlations between clinical features, erosion scores and urate crystal volume were analyzed by the Spearman correlation coefficient (r).<h4>Results</h4>We studied 61 patients (mean age 62.0 years); 3,751 bones were scored. The first metatarsophalangeal joint and the midfoot were the most involved in terms of frequency and severity of bone erosions. The distribution of bone erosions was not asymmetrical. The intra- and inter-observer reproducibility was similar for the RAMRIS and Dalbeth-simplified scores (ICC 0.93 vs 0.94 and 0.96 vs 0.90). DECT urate volume was significantly correlated with each of the two erosion scores (r = 0.58-0.63, p < 0.001). There was a high correlation between the two scores (r = 0.96, p < 0.001).<h4>Conclusions</h4>DECT demonstrates that foot erosions are not asymmetric in distribution and predominate at the first ray and midfoot. The two erosion scores are significantly correlated with DECT urate volume. An almost perfect correlation between the RAMRIS and Dalbeth-simplified scores is observed.
format	article
author	Amandine Chabernaud Negrier Lokmane Taihi Eric Vicaut Pascal Richette Thomas Bardin Frédéric Lioté Hang-Korng Ea Valérie Bousson
author_facet	Amandine Chabernaud Negrier Lokmane Taihi Eric Vicaut Pascal Richette Thomas Bardin Frédéric Lioté Hang-Korng Ea Valérie Bousson
author_sort	Amandine Chabernaud Negrier
title	Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.
title_short	Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.
title_full	Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.
title_fullStr	Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.
title_full_unstemmed	Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.
title_sort	distribution of bony erosions in feet and performance of two bone erosion scores: a dual-energy computed tomography study of 61 patients with gout.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/eaea0989959d4b6ab5dd5739064c865b
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Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout.

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