Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis

The cerebral folate receptor alpha (FRα) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). CFD has been associated with autism spectrum disorders (ASD) and is treated with <i>d,l</i>-leucovorin (folinic acid). On...

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Autores principales: Daniel A. Rossignol, Richard E. Frye
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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R
Acceso en línea:https://doaj.org/article/eaead278f9d34b0ab4270daa73bbb88c
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