Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis

Bacterial adaptation through frame-shifting insertions and deletions (indels) could be reversed by secondary introduction of a frame-restoring indel. Here, the authors develop ScarTrek, a program that scans genomic data for different indels, and analyze 5977 clinical M. tuberculosis isolates for ind...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aditi Gupta, David Alland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eaeb2ef159784c36a26c5cb80484bdc6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eaeb2ef159784c36a26c5cb80484bdc6
record_format	dspace
spelling	oai:doaj.org-article:eaeb2ef159784c36a26c5cb80484bdc62021-12-02T14:53:36ZReversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis10.1038/s41467-021-25055-y2041-1723https://doaj.org/article/eaeb2ef159784c36a26c5cb80484bdc62021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25055-yhttps://doaj.org/toc/2041-1723Bacterial adaptation through frame-shifting insertions and deletions (indels) could be reversed by secondary introduction of a frame-restoring indel. Here, the authors develop ScarTrek, a program that scans genomic data for different indels, and analyze 5977 clinical M. tuberculosis isolates for indel frequency.Aditi GuptaDavid AllandNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aditi Gupta David Alland Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis
description	Bacterial adaptation through frame-shifting insertions and deletions (indels) could be reversed by secondary introduction of a frame-restoring indel. Here, the authors develop ScarTrek, a program that scans genomic data for different indels, and analyze 5977 clinical M. tuberculosis isolates for indel frequency.
format	article
author	Aditi Gupta David Alland
author_facet	Aditi Gupta David Alland
author_sort	Aditi Gupta
title	Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis
title_short	Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis
title_full	Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis
title_fullStr	Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis
title_full_unstemmed	Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis
title_sort	reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eaeb2ef159784c36a26c5cb80484bdc6
work_keys_str_mv	AT aditigupta reversiblegenesilencingthroughframeshiftindelsandframeshiftscarsprovideadaptiveplasticityformycobacteriumtuberculosis AT davidalland reversiblegenesilencingthroughframeshiftindelsandframeshiftscarsprovideadaptiveplasticityformycobacteriumtuberculosis
_version_	1718389420879511552

Reversible gene silencing through frameshift indels and frameshift scars provide adaptive plasticity for Mycobacterium tuberculosis

Ejemplares similares