KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

Shimoda et al. present evidence that a small functional peptide derived from the KSHV transactivator could be used to target MYC in cancer. The authors find that the peptide attenuates MYC expression, reduces cell proliferation, and selectively kills cancer cells in tissue culture and a xenograft tu...

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Autores principales:	Michiko Shimoda, Yuanzhi Lyu, Kang-Hsin Wang, Ashish Kumar, Hiroki Miura, Joshua F. Meckler, Ryan R. Davis, Chanikarn Chantarasrivong, Chie Izumiya, Clifford G. Tepper, Ken-ichi Nakajima, Joseph Tuscano, Gustavo Barisone, Yoshihiro Izumiya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/eaec3f23d40d4e7a83a5c5ddca22da0a
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spelling	oai:doaj.org-article:eaec3f23d40d4e7a83a5c5ddca22da0a2021-12-05T12:08:21ZKSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth10.1038/s42003-021-02853-02399-3642https://doaj.org/article/eaec3f23d40d4e7a83a5c5ddca22da0a2021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02853-0https://doaj.org/toc/2399-3642Shimoda et al. present evidence that a small functional peptide derived from the KSHV transactivator could be used to target MYC in cancer. The authors find that the peptide attenuates MYC expression, reduces cell proliferation, and selectively kills cancer cells in tissue culture and a xenograft tumor mouse model, by blocking recruitment of coactivator complexes (Nuclear receptor coactivator 2, p300, and SWI/SNF proteins) to the MYC promoter.Michiko ShimodaYuanzhi LyuKang-Hsin WangAshish KumarHiroki MiuraJoshua F. MecklerRyan R. DavisChanikarn ChantarasrivongChie IzumiyaClifford G. TepperKen-ichi NakajimaJoseph TuscanoGustavo BarisoneYoshihiro IzumiyaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michiko Shimoda Yuanzhi Lyu Kang-Hsin Wang Ashish Kumar Hiroki Miura Joshua F. Meckler Ryan R. Davis Chanikarn Chantarasrivong Chie Izumiya Clifford G. Tepper Ken-ichi Nakajima Joseph Tuscano Gustavo Barisone Yoshihiro Izumiya KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth
description	Shimoda et al. present evidence that a small functional peptide derived from the KSHV transactivator could be used to target MYC in cancer. The authors find that the peptide attenuates MYC expression, reduces cell proliferation, and selectively kills cancer cells in tissue culture and a xenograft tumor mouse model, by blocking recruitment of coactivator complexes (Nuclear receptor coactivator 2, p300, and SWI/SNF proteins) to the MYC promoter.
format	article
author	Michiko Shimoda Yuanzhi Lyu Kang-Hsin Wang Ashish Kumar Hiroki Miura Joshua F. Meckler Ryan R. Davis Chanikarn Chantarasrivong Chie Izumiya Clifford G. Tepper Ken-ichi Nakajima Joseph Tuscano Gustavo Barisone Yoshihiro Izumiya
author_facet	Michiko Shimoda Yuanzhi Lyu Kang-Hsin Wang Ashish Kumar Hiroki Miura Joshua F. Meckler Ryan R. Davis Chanikarn Chantarasrivong Chie Izumiya Clifford G. Tepper Ken-ichi Nakajima Joseph Tuscano Gustavo Barisone Yoshihiro Izumiya
author_sort	Michiko Shimoda
title	KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth
title_short	KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth
title_full	KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth
title_fullStr	KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth
title_full_unstemmed	KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth
title_sort	kshv transactivator-derived small peptide traps coactivators to attenuate myc and inhibits leukemia and lymphoma cell growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eaec3f23d40d4e7a83a5c5ddca22da0a
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KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

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