Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions

Peroxisome proliferator-activated receptors (PPARs) are the nuclear receptors that could mediate the nutrient-dependent transcriptional activation and regulate metabolic networks through energy homeostasis. However, these receptors cannot work properly under metabolic stress. PPARs and their subtype...

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Autores principales:	Faiz-ul Hassan, Asif Nadeem, Zhipeng Li, Maryam Javed, Qingyou Liu, Jahanzaib Azhar, Muhammad Saif-ur Rehman, Kuiqing Cui, Saif ur Rehman
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nuclear receptors PPARs nutrigenomics energy homeostasis dairy animals Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/eaedddb305f64186a88655f6c35a3777
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spelling	oai:doaj.org-article:eaedddb305f64186a88655f6c35a37772021-11-25T17:56:51ZRole of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions10.3390/ijms2222124631422-00671661-6596https://doaj.org/article/eaedddb305f64186a88655f6c35a37772021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12463https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Peroxisome proliferator-activated receptors (PPARs) are the nuclear receptors that could mediate the nutrient-dependent transcriptional activation and regulate metabolic networks through energy homeostasis. However, these receptors cannot work properly under metabolic stress. PPARs and their subtypes can be modulated by nutrigenomic interventions, particularly under stress conditions to restore cellular homeostasis. Many nutrients such as polyunsaturated fatty acids, vitamins, dietary amino acids and phytochemicals have shown their ability for potential activation or inhibition of PPARs. Thus, through different mechanisms, all these nutrients can modulate PPARs and are ultimately helpful to prevent various metabolic disorders, particularly in transition dairy cows. This review aims to provide insights into the crucial role of PPARs in energy metabolism and their potential modulation through nutrigenomic interventions to improve energy homeostasis in dairy animals.Faiz-ul HassanAsif NadeemZhipeng LiMaryam JavedQingyou LiuJahanzaib AzharMuhammad Saif-ur RehmanKuiqing CuiSaif ur RehmanMDPI AGarticlenuclear receptorsPPARsnutrigenomicsenergy homeostasisdairy animalsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12463, p 12463 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nuclear receptors PPARs nutrigenomics energy homeostasis dairy animals Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	nuclear receptors PPARs nutrigenomics energy homeostasis dairy animals Biology (General) QH301-705.5 Chemistry QD1-999 Faiz-ul Hassan Asif Nadeem Zhipeng Li Maryam Javed Qingyou Liu Jahanzaib Azhar Muhammad Saif-ur Rehman Kuiqing Cui Saif ur Rehman Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
description	Peroxisome proliferator-activated receptors (PPARs) are the nuclear receptors that could mediate the nutrient-dependent transcriptional activation and regulate metabolic networks through energy homeostasis. However, these receptors cannot work properly under metabolic stress. PPARs and their subtypes can be modulated by nutrigenomic interventions, particularly under stress conditions to restore cellular homeostasis. Many nutrients such as polyunsaturated fatty acids, vitamins, dietary amino acids and phytochemicals have shown their ability for potential activation or inhibition of PPARs. Thus, through different mechanisms, all these nutrients can modulate PPARs and are ultimately helpful to prevent various metabolic disorders, particularly in transition dairy cows. This review aims to provide insights into the crucial role of PPARs in energy metabolism and their potential modulation through nutrigenomic interventions to improve energy homeostasis in dairy animals.
format	article
author	Faiz-ul Hassan Asif Nadeem Zhipeng Li Maryam Javed Qingyou Liu Jahanzaib Azhar Muhammad Saif-ur Rehman Kuiqing Cui Saif ur Rehman
author_facet	Faiz-ul Hassan Asif Nadeem Zhipeng Li Maryam Javed Qingyou Liu Jahanzaib Azhar Muhammad Saif-ur Rehman Kuiqing Cui Saif ur Rehman
author_sort	Faiz-ul Hassan
title	Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
title_short	Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
title_full	Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
title_fullStr	Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
title_full_unstemmed	Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
title_sort	role of peroxisome proliferator-activated receptors (ppars) in energy homeostasis of dairy animals: exploiting their modulation through nutrigenomic interventions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/eaedddb305f64186a88655f6c35a3777
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Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions

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