Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues

Abstract To investigate neuronal processing involved in the integration of auditory and visual signals for time perception, we examined neuronal activity in prefrontal cortex (PFC) of macaque monkeys during a duration discrimination task with auditory and visual cues. In the task, two cues were cons...

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Autores principales:	Atsushi Chiba, Kazunori Morita, Ken-ichi Oshio, Masahiko Inase
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eaee004566ad405c9856efef018de770
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spelling	oai:doaj.org-article:eaee004566ad405c9856efef018de7702021-12-02T16:38:25ZNeuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues10.1038/s41598-021-97094-w2045-2322https://doaj.org/article/eaee004566ad405c9856efef018de7702021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97094-whttps://doaj.org/toc/2045-2322Abstract To investigate neuronal processing involved in the integration of auditory and visual signals for time perception, we examined neuronal activity in prefrontal cortex (PFC) of macaque monkeys during a duration discrimination task with auditory and visual cues. In the task, two cues were consecutively presented for different durations between 0.2 and 1.8 s. Each cue was either auditory or visual and was followed by a delay period. After the second delay, subjects indicated whether the first or the second cue was longer. Cue- and delay-responsive neurons were found in PFC. Cue-responsive neurons mostly responded to either the auditory or the visual cue, and to either the first or the second cue. The neurons responsive to the first delay showed activity that changed depending on the first cue duration and were mostly sensitive to cue modality. The neurons responsive to the second delay exhibited activity that represented which cue, the first or second cue, was presented longer. Nearly half of this activity representing order-based duration was sensitive to cue modality. These results suggest that temporal information with visual and auditory signals was separately processed in PFC in the early stage of duration discrimination and integrated for the final decision.Atsushi ChibaKazunori MoritaKen-ichi OshioMasahiko InaseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsushi Chiba Kazunori Morita Ken-ichi Oshio Masahiko Inase Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues
description	Abstract To investigate neuronal processing involved in the integration of auditory and visual signals for time perception, we examined neuronal activity in prefrontal cortex (PFC) of macaque monkeys during a duration discrimination task with auditory and visual cues. In the task, two cues were consecutively presented for different durations between 0.2 and 1.8 s. Each cue was either auditory or visual and was followed by a delay period. After the second delay, subjects indicated whether the first or the second cue was longer. Cue- and delay-responsive neurons were found in PFC. Cue-responsive neurons mostly responded to either the auditory or the visual cue, and to either the first or the second cue. The neurons responsive to the first delay showed activity that changed depending on the first cue duration and were mostly sensitive to cue modality. The neurons responsive to the second delay exhibited activity that represented which cue, the first or second cue, was presented longer. Nearly half of this activity representing order-based duration was sensitive to cue modality. These results suggest that temporal information with visual and auditory signals was separately processed in PFC in the early stage of duration discrimination and integrated for the final decision.
format	article
author	Atsushi Chiba Kazunori Morita Ken-ichi Oshio Masahiko Inase
author_facet	Atsushi Chiba Kazunori Morita Ken-ichi Oshio Masahiko Inase
author_sort	Atsushi Chiba
title	Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues
title_short	Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues
title_full	Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues
title_fullStr	Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues
title_full_unstemmed	Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues
title_sort	neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eaee004566ad405c9856efef018de770
work_keys_str_mv	AT atsushichiba neuronalactivityinthemonkeyprefrontalcortexduringadurationdiscriminationtaskwithvisualandauditorycues AT kazunorimorita neuronalactivityinthemonkeyprefrontalcortexduringadurationdiscriminationtaskwithvisualandauditorycues AT kenichioshio neuronalactivityinthemonkeyprefrontalcortexduringadurationdiscriminationtaskwithvisualandauditorycues AT masahikoinase neuronalactivityinthemonkeyprefrontalcortexduringadurationdiscriminationtaskwithvisualandauditorycues
_version_	1718383607515447296

Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues

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