A putative “chemokine switch” that regulates systemic acute inflammation in humans

Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients. Using dynamic network analyses, we inferred a no...

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Autores principales:	Nabil Azhar, Rami A. Namas, Khalid Almahmoud, Akram Zaaqoq, Othman A. Malak, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Andrew Abboud, Richard L. Simmons, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc50
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spelling	oai:doaj.org-article:eaee90484a5b42d6b93c66d1d070bc502021-12-02T15:38:10ZA putative “chemokine switch” that regulates systemic acute inflammation in humans10.1038/s41598-021-88936-82045-2322https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc502021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88936-8https://doaj.org/toc/2045-2322Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients. Using dynamic network analyses, we inferred a novel control architecture for systemic inflammation: a three-way switch comprising the chemokines MCP-1/CCL2, MIG/CXCL9, and IP-10/CXCL10. To test this hypothesis, we created a logical model comprising this putative architecture. This model predicted key qualitative features of systemic inflammation in patient sub-groups, as well as the different patterns of hospital discharge of moderately vs. severely injured patients. Thus, a rational transition from data to data-driven models to mechanistic models suggests a novel, chemokine-based mechanism for control of acute inflammation in humans and points to the potential utility of this workflow in defining novel features in other complex diseases.Nabil AzharRami A. NamasKhalid AlmahmoudAkram ZaaqoqOthman A. MalakDerek BarclayJinling YinFayten El-DehaibiAndrew AbboudRichard L. SimmonsRuben ZamoraTimothy R. BilliarYoram VodovotzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nabil Azhar Rami A. Namas Khalid Almahmoud Akram Zaaqoq Othman A. Malak Derek Barclay Jinling Yin Fayten El-Dehaibi Andrew Abboud Richard L. Simmons Ruben Zamora Timothy R. Billiar Yoram Vodovotz A putative “chemokine switch” that regulates systemic acute inflammation in humans
description	Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients. Using dynamic network analyses, we inferred a novel control architecture for systemic inflammation: a three-way switch comprising the chemokines MCP-1/CCL2, MIG/CXCL9, and IP-10/CXCL10. To test this hypothesis, we created a logical model comprising this putative architecture. This model predicted key qualitative features of systemic inflammation in patient sub-groups, as well as the different patterns of hospital discharge of moderately vs. severely injured patients. Thus, a rational transition from data to data-driven models to mechanistic models suggests a novel, chemokine-based mechanism for control of acute inflammation in humans and points to the potential utility of this workflow in defining novel features in other complex diseases.
format	article
author	Nabil Azhar Rami A. Namas Khalid Almahmoud Akram Zaaqoq Othman A. Malak Derek Barclay Jinling Yin Fayten El-Dehaibi Andrew Abboud Richard L. Simmons Ruben Zamora Timothy R. Billiar Yoram Vodovotz
author_facet	Nabil Azhar Rami A. Namas Khalid Almahmoud Akram Zaaqoq Othman A. Malak Derek Barclay Jinling Yin Fayten El-Dehaibi Andrew Abboud Richard L. Simmons Ruben Zamora Timothy R. Billiar Yoram Vodovotz
author_sort	Nabil Azhar
title	A putative “chemokine switch” that regulates systemic acute inflammation in humans
title_short	A putative “chemokine switch” that regulates systemic acute inflammation in humans
title_full	A putative “chemokine switch” that regulates systemic acute inflammation in humans
title_fullStr	A putative “chemokine switch” that regulates systemic acute inflammation in humans
title_full_unstemmed	A putative “chemokine switch” that regulates systemic acute inflammation in humans
title_sort	putative “chemokine switch” that regulates systemic acute inflammation in humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc50
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A putative “chemokine switch” that regulates systemic acute inflammation in humans

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