Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

It is unclear how circuit specificity and function are maintained during organismal growth. In this study, authors show that connectivity between primary nociceptors and their downstream neurons scales with animal size and that Ste20-like kinase Tao acts as a negative regulator of synaptic growth re...

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Autores principales:	Federico Marcello Tenedini, Maria Sáez González, Chun Hu, Lisa Hedegaard Pedersen, Mabel Matamala Petruzzi, Bettina Spitzweck, Denan Wang, Melanie Richter, Meike Petersen, Emanuela Szpotowicz, Michaela Schweizer, Stephan J. Sigrist, Froylan Calderon de Anda, Peter Soba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eaf1877c7d184c2b88e5164aa3d00891
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spelling	oai:doaj.org-article:eaf1877c7d184c2b88e5164aa3d008912021-12-02T14:40:21ZMaintenance of cell type-specific connectivity and circuit function requires Tao kinase10.1038/s41467-019-11408-12041-1723https://doaj.org/article/eaf1877c7d184c2b88e5164aa3d008912019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11408-1https://doaj.org/toc/2041-1723It is unclear how circuit specificity and function are maintained during organismal growth. In this study, authors show that connectivity between primary nociceptors and their downstream neurons scales with animal size and that Ste20-like kinase Tao acts as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity.Federico Marcello TenediniMaria Sáez GonzálezChun HuLisa Hedegaard PedersenMabel Matamala PetruzziBettina SpitzweckDenan WangMelanie RichterMeike PetersenEmanuela SzpotowiczMichaela SchweizerStephan J. SigristFroylan Calderon de AndaPeter SobaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Federico Marcello Tenedini Maria Sáez González Chun Hu Lisa Hedegaard Pedersen Mabel Matamala Petruzzi Bettina Spitzweck Denan Wang Melanie Richter Meike Petersen Emanuela Szpotowicz Michaela Schweizer Stephan J. Sigrist Froylan Calderon de Anda Peter Soba Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
description	It is unclear how circuit specificity and function are maintained during organismal growth. In this study, authors show that connectivity between primary nociceptors and their downstream neurons scales with animal size and that Ste20-like kinase Tao acts as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity.
format	article
author	Federico Marcello Tenedini Maria Sáez González Chun Hu Lisa Hedegaard Pedersen Mabel Matamala Petruzzi Bettina Spitzweck Denan Wang Melanie Richter Meike Petersen Emanuela Szpotowicz Michaela Schweizer Stephan J. Sigrist Froylan Calderon de Anda Peter Soba
author_facet	Federico Marcello Tenedini Maria Sáez González Chun Hu Lisa Hedegaard Pedersen Mabel Matamala Petruzzi Bettina Spitzweck Denan Wang Melanie Richter Meike Petersen Emanuela Szpotowicz Michaela Schweizer Stephan J. Sigrist Froylan Calderon de Anda Peter Soba
author_sort	Federico Marcello Tenedini
title	Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
title_short	Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
title_full	Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
title_fullStr	Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
title_full_unstemmed	Maintenance of cell type-specific connectivity and circuit function requires Tao kinase
title_sort	maintenance of cell type-specific connectivity and circuit function requires tao kinase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eaf1877c7d184c2b88e5164aa3d00891
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Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

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