Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

Topoisomerase 1 (TOP1) relieves superhelical tension when DNA strands are unwound during transcription. Here, Husain et al. report that SMARCA4, an ATP-dependent chromatin remodeller, is associated with TOP1 and suppresses transcription-associated genomic instability.

Guardado en:

Detalles Bibliográficos
Autores principales:	Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi, Tasuku Honjo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eaf6c6b8283440a09e77451e98b651c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eaf6c6b8283440a09e77451e98b651c1
record_format	dspace
spelling	oai:doaj.org-article:eaf6c6b8283440a09e77451e98b651c12021-12-02T14:39:14ZChromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability10.1038/ncomms105492041-1723https://doaj.org/article/eaf6c6b8283440a09e77451e98b651c12016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10549https://doaj.org/toc/2041-1723Topoisomerase 1 (TOP1) relieves superhelical tension when DNA strands are unwound during transcription. Here, Husain et al. report that SMARCA4, an ATP-dependent chromatin remodeller, is associated with TOP1 and suppresses transcription-associated genomic instability.Afzal HusainNasim A. BegumTakako TaniguchiHisaaki TaniguchiMaki KobayashiTasuku HonjoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Afzal Husain Nasim A. Begum Takako Taniguchi Hisaaki Taniguchi Maki Kobayashi Tasuku Honjo Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
description	Topoisomerase 1 (TOP1) relieves superhelical tension when DNA strands are unwound during transcription. Here, Husain et al. report that SMARCA4, an ATP-dependent chromatin remodeller, is associated with TOP1 and suppresses transcription-associated genomic instability.
format	article
author	Afzal Husain Nasim A. Begum Takako Taniguchi Hisaaki Taniguchi Maki Kobayashi Tasuku Honjo
author_facet	Afzal Husain Nasim A. Begum Takako Taniguchi Hisaaki Taniguchi Maki Kobayashi Tasuku Honjo
author_sort	Afzal Husain
title	Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
title_short	Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
title_full	Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
title_fullStr	Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
title_full_unstemmed	Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
title_sort	chromatin remodeller smarca4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/eaf6c6b8283440a09e77451e98b651c1
work_keys_str_mv	AT afzalhusain chromatinremodellersmarca4recruitstopoisomerase1andsuppressestranscriptionassociatedgenomicinstability AT nasimabegum chromatinremodellersmarca4recruitstopoisomerase1andsuppressestranscriptionassociatedgenomicinstability AT takakotaniguchi chromatinremodellersmarca4recruitstopoisomerase1andsuppressestranscriptionassociatedgenomicinstability AT hisaakitaniguchi chromatinremodellersmarca4recruitstopoisomerase1andsuppressestranscriptionassociatedgenomicinstability AT makikobayashi chromatinremodellersmarca4recruitstopoisomerase1andsuppressestranscriptionassociatedgenomicinstability AT tasukuhonjo chromatinremodellersmarca4recruitstopoisomerase1andsuppressestranscriptionassociatedgenomicinstability
_version_	1718390746218758144

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

Ejemplares similares