From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review

The pathophysiology of myelodysplastic syndromes (MDSs) is complex and often includes immune dysregulation of both the innate and adaptive immune systems. Whereas clonal selection mainly involves smoldering inflammation, a cellular immunity dysfunction leads to increased apoptosis and blast prolifer...

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Autores principales:	Thibault Comont, Emmanuel Treiner, François Vergez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	myelodysplastic syndromes immune inflammation T-cell Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eafaa3a4705946218f780915a470f3a7
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spelling	oai:doaj.org-article:eafaa3a4705946218f780915a470f3a72021-11-25T17:20:28ZFrom Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review10.3390/diagnostics111119822075-4418https://doaj.org/article/eafaa3a4705946218f780915a470f3a72021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1982https://doaj.org/toc/2075-4418The pathophysiology of myelodysplastic syndromes (MDSs) is complex and often includes immune dysregulation of both the innate and adaptive immune systems. Whereas clonal selection mainly involves smoldering inflammation, a cellular immunity dysfunction leads to increased apoptosis and blast proliferation. Addressing immune dysregulations in MDS is a recent concept that has allowed the identification of new therapeutic targets. Several approaches targeting the different actors of the immune system have therefore been developed. However, the results are very heterogeneous, indicating the need to improve our understanding of the disease and interactions between chronic inflammation, adaptive dysfunction, and somatic mutations. This review highlights current knowledge of the role of immune dysregulation in MDS pathophysiology and the field of new drugs.Thibault ComontEmmanuel TreinerFrançois VergezMDPI AGarticlemyelodysplastic syndromesimmuneinflammationT-cellMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1982, p 1982 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	myelodysplastic syndromes immune inflammation T-cell Medicine (General) R5-920
spellingShingle	myelodysplastic syndromes immune inflammation T-cell Medicine (General) R5-920 Thibault Comont Emmanuel Treiner François Vergez From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review
description	The pathophysiology of myelodysplastic syndromes (MDSs) is complex and often includes immune dysregulation of both the innate and adaptive immune systems. Whereas clonal selection mainly involves smoldering inflammation, a cellular immunity dysfunction leads to increased apoptosis and blast proliferation. Addressing immune dysregulations in MDS is a recent concept that has allowed the identification of new therapeutic targets. Several approaches targeting the different actors of the immune system have therefore been developed. However, the results are very heterogeneous, indicating the need to improve our understanding of the disease and interactions between chronic inflammation, adaptive dysfunction, and somatic mutations. This review highlights current knowledge of the role of immune dysregulation in MDS pathophysiology and the field of new drugs.
format	article
author	Thibault Comont Emmanuel Treiner François Vergez
author_facet	Thibault Comont Emmanuel Treiner François Vergez
author_sort	Thibault Comont
title	From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review
title_short	From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review
title_full	From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review
title_fullStr	From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review
title_full_unstemmed	From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review
title_sort	from immune dysregulations to therapeutic perspectives in myelodysplastic syndromes: a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/eafaa3a4705946218f780915a470f3a7
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From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review

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