LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
LIF is a pleiotropic cytokine that promotes an immunosuppressive microenvironment and has critical functions in embryonic development. Here, the authors show that LIF regulates CD8+ T cell tumor infiltration in cancer by repressing CXCL19 and promoting the presence of protumoral macrophages and that...
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Nature Portfolio
2019
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oai:doaj.org-article:eafd754e38d148f4af2177cb43fd4fa52021-12-02T14:39:18ZLIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy10.1038/s41467-019-10369-92041-1723https://doaj.org/article/eafd754e38d148f4af2177cb43fd4fa52019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10369-9https://doaj.org/toc/2041-1723LIF is a pleiotropic cytokine that promotes an immunosuppressive microenvironment and has critical functions in embryonic development. Here, the authors show that LIF regulates CD8+ T cell tumor infiltration in cancer by repressing CXCL19 and promoting the presence of protumoral macrophages and thatLIF inhibition, via neutralizing antibodies, promotes T cell infiltration and synergizes with immune checkpoint inhbitors resulting in tumor regression and immunological memory.Mónica Pascual-GarcíaEster Bonfill-TeixidorEster Planas-RigolCarlota Rubio-PerezRaffaella IurlaroAlexandra AriasIsabel CuartasAda Sala-HojmanLaura EscuderoFrancisco Martínez-RicarteIsabel Huber-RuanoPaolo NuciforoLeire PedrosaCarolina MarquesIrene BrañaElena GarraldaMaría VieitoMassimo SquatritoEstela PinedaFrancesc GrausCarmen EspejoJuan SahuquilloJosep TaberneroJoan SeoaneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
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Science Q Mónica Pascual-García Ester Bonfill-Teixidor Ester Planas-Rigol Carlota Rubio-Perez Raffaella Iurlaro Alexandra Arias Isabel Cuartas Ada Sala-Hojman Laura Escudero Francisco Martínez-Ricarte Isabel Huber-Ruano Paolo Nuciforo Leire Pedrosa Carolina Marques Irene Braña Elena Garralda María Vieito Massimo Squatrito Estela Pineda Francesc Graus Carmen Espejo Juan Sahuquillo Josep Tabernero Joan Seoane LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy |
| description |
LIF is a pleiotropic cytokine that promotes an immunosuppressive microenvironment and has critical functions in embryonic development. Here, the authors show that LIF regulates CD8+ T cell tumor infiltration in cancer by repressing CXCL19 and promoting the presence of protumoral macrophages and thatLIF inhibition, via neutralizing antibodies, promotes T cell infiltration and synergizes with immune checkpoint inhbitors resulting in tumor regression and immunological memory. |
| format |
article |
| author |
Mónica Pascual-García Ester Bonfill-Teixidor Ester Planas-Rigol Carlota Rubio-Perez Raffaella Iurlaro Alexandra Arias Isabel Cuartas Ada Sala-Hojman Laura Escudero Francisco Martínez-Ricarte Isabel Huber-Ruano Paolo Nuciforo Leire Pedrosa Carolina Marques Irene Braña Elena Garralda María Vieito Massimo Squatrito Estela Pineda Francesc Graus Carmen Espejo Juan Sahuquillo Josep Tabernero Joan Seoane |
| author_facet |
Mónica Pascual-García Ester Bonfill-Teixidor Ester Planas-Rigol Carlota Rubio-Perez Raffaella Iurlaro Alexandra Arias Isabel Cuartas Ada Sala-Hojman Laura Escudero Francisco Martínez-Ricarte Isabel Huber-Ruano Paolo Nuciforo Leire Pedrosa Carolina Marques Irene Braña Elena Garralda María Vieito Massimo Squatrito Estela Pineda Francesc Graus Carmen Espejo Juan Sahuquillo Josep Tabernero Joan Seoane |
| author_sort |
Mónica Pascual-García |
| title |
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy |
| title_short |
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy |
| title_full |
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy |
| title_fullStr |
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy |
| title_full_unstemmed |
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy |
| title_sort |
lif regulates cxcl9 in tumor-associated macrophages and prevents cd8+ t cell tumor-infiltration impairing anti-pd1 therapy |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/eafd754e38d148f4af2177cb43fd4fa5 |
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