Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+overcome the immune suppression at the t...

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Autores principales:	Kyun-Do Kim, Seyeon Bae, Tara Capece, Hristina Nedelkovska, Rafael G. de Rubio, Alan V. Smrcka, Chang-Duk Jun, Woojin Jung, Byeonghak Park, Tae-il Kim, Minsoo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eaff6961123b44e39ab2cbba3d2edb63
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spelling	oai:doaj.org-article:eaff6961123b44e39ab2cbba3d2edb632021-12-02T14:42:09ZTargeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment10.1038/ncomms153652041-1723https://doaj.org/article/eaff6961123b44e39ab2cbba3d2edb632017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15365https://doaj.org/toc/2041-1723Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+overcome the immune suppression at the tumour site.Kyun-Do KimSeyeon BaeTara CapeceHristina NedelkovskaRafael G. de RubioAlan V. SmrckaChang-Duk JunWoojin JungByeonghak ParkTae-il KimMinsoo KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyun-Do Kim Seyeon Bae Tara Capece Hristina Nedelkovska Rafael G. de Rubio Alan V. Smrcka Chang-Duk Jun Woojin Jung Byeonghak Park Tae-il Kim Minsoo Kim Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
description	Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+overcome the immune suppression at the tumour site.
format	article
author	Kyun-Do Kim Seyeon Bae Tara Capece Hristina Nedelkovska Rafael G. de Rubio Alan V. Smrcka Chang-Duk Jun Woojin Jung Byeonghak Park Tae-il Kim Minsoo Kim
author_facet	Kyun-Do Kim Seyeon Bae Tara Capece Hristina Nedelkovska Rafael G. de Rubio Alan V. Smrcka Chang-Duk Jun Woojin Jung Byeonghak Park Tae-il Kim Minsoo Kim
author_sort	Kyun-Do Kim
title	Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
title_short	Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
title_full	Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
title_fullStr	Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
title_full_unstemmed	Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
title_sort	targeted calcium influx boosts cytotoxic t lymphocyte function in the tumour microenvironment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eaff6961123b44e39ab2cbba3d2edb63
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Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

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