Promoting vascular healing using nanofibrous ticagrelor-eluting stents

Cheng-Hung Lee,1 Ming-Jer Hsieh,1 Kuo-Sheng Liu,2,3 Che-Wei Cheng,3 Shang-Hung Chang,1 Shih-Jung Liu,3,4 Chao-Jan Wang,5 Ming-Yi Hsu,5 Kuo-Chun Hung,1 Yung-Hsin Yeh,1 Wei-Jan Chen,1 I-Chang Hsieh,1 Jyuhn-Huarng Juang,6 Ming-Shien Wen1 1Division of Cardiology, Department of Internal Medicine, Chang...

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Autores principales:	Lee CH, Hsieh MJ, Liu KS, Cheng CW, Chang SH, Liu SJ, Wang CJ, Hsu MY, Hung KC, Yeh YH, Chen WJ, Hsieh IC, Juang JH, Wen MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	ticagrelor drug-eluting stents electrospinning endothelialization neointimal hyperplasia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eb03ac5e5bab433197aa2852c87f69dd
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spelling	oai:doaj.org-article:eb03ac5e5bab433197aa2852c87f69dd2021-12-02T04:01:12ZPromoting vascular healing using nanofibrous ticagrelor-eluting stents1178-2013https://doaj.org/article/eb03ac5e5bab433197aa2852c87f69dd2018-10-01T00:00:00Zhttps://www.dovepress.com/promoting-vascular-healing-using-nanofibrous-ticagrelor-eluting-stents-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Cheng-Hung Lee,1 Ming-Jer Hsieh,1 Kuo-Sheng Liu,2,3 Che-Wei Cheng,3 Shang-Hung Chang,1 Shih-Jung Liu,3,4 Chao-Jan Wang,5 Ming-Yi Hsu,5 Kuo-Chun Hung,1 Yung-Hsin Yeh,1 Wei-Jan Chen,1 I-Chang Hsieh,1 Jyuhn-Huarng Juang,6 Ming-Shien Wen1 1Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Tao-Yuan, Taiwan; 2Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Linkou, Tao-Yuan, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan; 4Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; 5Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Tao-Yuan, Taiwan; 6Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung University and Chang Gung Memorial Hospital, Tao-Yuan, Taiwan Objective: The current treatment of atherosclerotic coronary heart disease with limus-eluting stents can lead to incomplete endothelialization and substantial impairment of arterial healing relative to treatment with bare-metal stents. The sustained and local delivery of ticagrelor, a reversibly binding P2Y12 receptor inhibitor, using hybrid biodegradable nanofibers/stents, was developed to reduce neointimal formation and endothelial dysfunction.Methods: In this investigation, a solution of ticagrelor, poly(D,L)-lactide-co-glycolide, and hexafluoro isopropanol was electrospun to fabricate ticagrelor-eluting nanofibrous drug-eluting stents. The in vitro and in vivo ticagrelor concentrations were measured using a high-performance liquid chromatography assay. The effectiveness of ticagrelor-eluting stents was examined relative to that of sirolimus-eluting stents. Results: Adequate ticagrelor levels were detected for four weeks in vitro. Less HES5-positive labeling was found near the ticagrelor-eluting stented vessels (0.33±0.12) than close to the sirolimus-eluting stented vessels (0.57±0.15) (p<0.05). Four weeks after deployment, the ticagrelor-eluting stent also exhibited an up-regulated local expression of SOD1 in the stenting area (p<0.001). The ticagrelor-eluting stent substantially preserved endothelial function and re-endothelialization, minimized inflammatory responses, and inhibited neointimal hyperplasia.Conclusion: Ticagrelor-eluting stents may provide an alternative route for treating patients at a high risk of bleeding to preserve endothelial recovery and to reduce smooth muscle proliferation. Keywords: ticagrelor, drug-eluting stents, electrospinning, endothelialization, neointimal hyperplasiaLee CHHsieh MJLiu KSCheng CWChang SHLiu SJWang CJHsu MYHung KCYeh YHChen WJHsieh ICJuang JHWen MSDove Medical Pressarticleticagrelordrug-eluting stentselectrospinningendothelializationneointimal hyperplasiaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 6039-6048 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ticagrelor drug-eluting stents electrospinning endothelialization neointimal hyperplasia Medicine (General) R5-920
spellingShingle	ticagrelor drug-eluting stents electrospinning endothelialization neointimal hyperplasia Medicine (General) R5-920 Lee CH Hsieh MJ Liu KS Cheng CW Chang SH Liu SJ Wang CJ Hsu MY Hung KC Yeh YH Chen WJ Hsieh IC Juang JH Wen MS Promoting vascular healing using nanofibrous ticagrelor-eluting stents
description	Cheng-Hung Lee,1 Ming-Jer Hsieh,1 Kuo-Sheng Liu,2,3 Che-Wei Cheng,3 Shang-Hung Chang,1 Shih-Jung Liu,3,4 Chao-Jan Wang,5 Ming-Yi Hsu,5 Kuo-Chun Hung,1 Yung-Hsin Yeh,1 Wei-Jan Chen,1 I-Chang Hsieh,1 Jyuhn-Huarng Juang,6 Ming-Shien Wen1 1Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Tao-Yuan, Taiwan; 2Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Linkou, Tao-Yuan, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan; 4Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; 5Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Tao-Yuan, Taiwan; 6Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung University and Chang Gung Memorial Hospital, Tao-Yuan, Taiwan Objective: The current treatment of atherosclerotic coronary heart disease with limus-eluting stents can lead to incomplete endothelialization and substantial impairment of arterial healing relative to treatment with bare-metal stents. The sustained and local delivery of ticagrelor, a reversibly binding P2Y12 receptor inhibitor, using hybrid biodegradable nanofibers/stents, was developed to reduce neointimal formation and endothelial dysfunction.Methods: In this investigation, a solution of ticagrelor, poly(D,L)-lactide-co-glycolide, and hexafluoro isopropanol was electrospun to fabricate ticagrelor-eluting nanofibrous drug-eluting stents. The in vitro and in vivo ticagrelor concentrations were measured using a high-performance liquid chromatography assay. The effectiveness of ticagrelor-eluting stents was examined relative to that of sirolimus-eluting stents. Results: Adequate ticagrelor levels were detected for four weeks in vitro. Less HES5-positive labeling was found near the ticagrelor-eluting stented vessels (0.33±0.12) than close to the sirolimus-eluting stented vessels (0.57±0.15) (p<0.05). Four weeks after deployment, the ticagrelor-eluting stent also exhibited an up-regulated local expression of SOD1 in the stenting area (p<0.001). The ticagrelor-eluting stent substantially preserved endothelial function and re-endothelialization, minimized inflammatory responses, and inhibited neointimal hyperplasia.Conclusion: Ticagrelor-eluting stents may provide an alternative route for treating patients at a high risk of bleeding to preserve endothelial recovery and to reduce smooth muscle proliferation. Keywords: ticagrelor, drug-eluting stents, electrospinning, endothelialization, neointimal hyperplasia
format	article
author	Lee CH Hsieh MJ Liu KS Cheng CW Chang SH Liu SJ Wang CJ Hsu MY Hung KC Yeh YH Chen WJ Hsieh IC Juang JH Wen MS
author_facet	Lee CH Hsieh MJ Liu KS Cheng CW Chang SH Liu SJ Wang CJ Hsu MY Hung KC Yeh YH Chen WJ Hsieh IC Juang JH Wen MS
author_sort	Lee CH
title	Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_short	Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_full	Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_fullStr	Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_full_unstemmed	Promoting vascular healing using nanofibrous ticagrelor-eluting stents
title_sort	promoting vascular healing using nanofibrous ticagrelor-eluting stents
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/eb03ac5e5bab433197aa2852c87f69dd
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Promoting vascular healing using nanofibrous ticagrelor-eluting stents

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