Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue

Abstract Endocrine disrupting chemicals (EDCs) are organic compounds that have estrogenic activity and can interfere with the endocrine system. Bisphenol-A (BPA) is one of these compounds which possess a potential risk for breast cancer. The aim of this research was to evaluate BPA concentration in...

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Autores principales:	Razieh Keshavarz-Maleki, Ahmad Kaviani, Ramesh Omranipour, Maryam Gholami, Mohammad Reza Khoshayand, Seyed Nasser Ostad, Omid Sabzevari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb052321f05c4b63bb8a7822c330c8c7
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spelling	oai:doaj.org-article:eb052321f05c4b63bb8a7822c330c8c72021-12-02T18:50:48ZBisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue10.1038/s41598-021-97864-62045-2322https://doaj.org/article/eb052321f05c4b63bb8a7822c330c8c72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97864-6https://doaj.org/toc/2045-2322Abstract Endocrine disrupting chemicals (EDCs) are organic compounds that have estrogenic activity and can interfere with the endocrine system. Bisphenol-A (BPA) is one of these compounds which possess a potential risk for breast cancer. The aim of this research was to evaluate BPA concentration in both the urine and breast adipose tissue samples of breast cancer mastectomy and mammoplasty patients and study correlations of BPA levels in breast adipose tissue with urine samples in the both groups. Urine and breast adipose tissue samples from 41 breast cancer mastectomy and 11 mammoplasty patients were taken. BPA concentrations were detected using an ELISA assay. Urinary BPA concentrations were significantly higher in cancerous patients (2.12 ± 1.48 ng/ml; P < 0.01) compared to non-cancerous (0.91 ± 0.42 ng/ml). Likewise, tissue BPA concentrations in cancerous patients (4.20 ± 2.40 ng/g tissue; P < 0.01) were significantly higher than non- cancerous (1.80 ± 1.05 ng/g tissue). Urinary BPA concentrations were positively correlated with breast adipose tissue BPA in the case group (P < 0.001, R = 0.896). We showed that BPA was present in urine and breast adipose tissue samples of the studied populations. With regard to higher BPA mean concentration in cancerous patients than non-cancerous individuals in this study, BPA might increase the risk of breast cancer incidence.Razieh Keshavarz-MalekiAhmad KavianiRamesh OmranipourMaryam GholamiMohammad Reza KhoshayandSeyed Nasser OstadOmid SabzevariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Razieh Keshavarz-Maleki Ahmad Kaviani Ramesh Omranipour Maryam Gholami Mohammad Reza Khoshayand Seyed Nasser Ostad Omid Sabzevari Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
description	Abstract Endocrine disrupting chemicals (EDCs) are organic compounds that have estrogenic activity and can interfere with the endocrine system. Bisphenol-A (BPA) is one of these compounds which possess a potential risk for breast cancer. The aim of this research was to evaluate BPA concentration in both the urine and breast adipose tissue samples of breast cancer mastectomy and mammoplasty patients and study correlations of BPA levels in breast adipose tissue with urine samples in the both groups. Urine and breast adipose tissue samples from 41 breast cancer mastectomy and 11 mammoplasty patients were taken. BPA concentrations were detected using an ELISA assay. Urinary BPA concentrations were significantly higher in cancerous patients (2.12 ± 1.48 ng/ml; P < 0.01) compared to non-cancerous (0.91 ± 0.42 ng/ml). Likewise, tissue BPA concentrations in cancerous patients (4.20 ± 2.40 ng/g tissue; P < 0.01) were significantly higher than non- cancerous (1.80 ± 1.05 ng/g tissue). Urinary BPA concentrations were positively correlated with breast adipose tissue BPA in the case group (P < 0.001, R = 0.896). We showed that BPA was present in urine and breast adipose tissue samples of the studied populations. With regard to higher BPA mean concentration in cancerous patients than non-cancerous individuals in this study, BPA might increase the risk of breast cancer incidence.
format	article
author	Razieh Keshavarz-Maleki Ahmad Kaviani Ramesh Omranipour Maryam Gholami Mohammad Reza Khoshayand Seyed Nasser Ostad Omid Sabzevari
author_facet	Razieh Keshavarz-Maleki Ahmad Kaviani Ramesh Omranipour Maryam Gholami Mohammad Reza Khoshayand Seyed Nasser Ostad Omid Sabzevari
author_sort	Razieh Keshavarz-Maleki
title	Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
title_short	Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
title_full	Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
title_fullStr	Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
title_full_unstemmed	Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
title_sort	bisphenol-a in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb052321f05c4b63bb8a7822c330c8c7
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Bisphenol-A in biological samples of breast cancer mastectomy and mammoplasty patients and correlation with levels measured in urine and tissue

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