Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon
Objective: Variants of concern (VOCs) associated with relatively high transmissibility appear to be rapidly spreading in Gabon. Therefore, it is imperative to understand the distribution of several VOCs in the population, which could have implications for transmissibility and vaccine efficacy. Metho...
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Elsevier
2022
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oai:doaj.org-article:eb05be132adc4cef94d189bea0a38b962021-12-04T04:33:20ZEmergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon1201-971210.1016/j.ijid.2021.10.057https://doaj.org/article/eb05be132adc4cef94d189bea0a38b962022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008468https://doaj.org/toc/1201-9712Objective: Variants of concern (VOCs) associated with relatively high transmissibility appear to be rapidly spreading in Gabon. Therefore, it is imperative to understand the distribution of several VOCs in the population, which could have implications for transmissibility and vaccine efficacy. Methods: Between February and May 2021, SARS-CoV-2 genomes were sequenced using the Oxford nanopore MinION method and the respective genome diversity was elucidated. Phylogenetic analysis was performed and genomes were classified using pangolin lineages. Results: The results highlighted an increase (46%) in the alpha VOC (B.1.1.7) in the Gabonese population over the study period. In addition, an increase (31%) in the B.1.1.318 lineage, which is associated with high transmission and impaired vaccine efficacy (D614G+E484K+Y144del), was detected. Conclusion: With the second wave ongoing, these findings highlight the need for surveillance of the SARS-CoV-2 genome in the Republic of Gabon and should provide useful guidance to policymakers in selecting an appropriate vaccine for this population.Gédéon Prince ManouanaMoustapha Nzamba MaloumRodrigue BikanguiSam O'neilla Oye BingonoGeorgelin Ondo NguemaJosiane Yabo HonkpehedjiElie Gide RossatangaSamira Zoa-AssoumouSrinivas Reddy PallerlaSivaramakrishna RachakondaArmel Ndong MintsaJean-Bernard Lekana-DoukiJoël-Fleury Djoba SiawayaSteffen BorrmannPeter Gottfried KremsnerBertrand LellThirumalaisamy P. VelavanAyola Akim AdegnikaElsevierarticleSARS-CoV-2B.1.1.318Variant of concernB.1.1.7TransmissionGabonInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 114, Iss , Pp 151-154 (2022) |
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SARS-CoV-2 B.1.1.318 Variant of concern B.1.1.7 Transmission Gabon Infectious and parasitic diseases RC109-216 |
| spellingShingle |
SARS-CoV-2 B.1.1.318 Variant of concern B.1.1.7 Transmission Gabon Infectious and parasitic diseases RC109-216 Gédéon Prince Manouana Moustapha Nzamba Maloum Rodrigue Bikangui Sam O'neilla Oye Bingono Georgelin Ondo Nguema Josiane Yabo Honkpehedji Elie Gide Rossatanga Samira Zoa-Assoumou Srinivas Reddy Pallerla Sivaramakrishna Rachakonda Armel Ndong Mintsa Jean-Bernard Lekana-Douki Joël-Fleury Djoba Siawaya Steffen Borrmann Peter Gottfried Kremsner Bertrand Lell Thirumalaisamy P. Velavan Ayola Akim Adegnika Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon |
| description |
Objective: Variants of concern (VOCs) associated with relatively high transmissibility appear to be rapidly spreading in Gabon. Therefore, it is imperative to understand the distribution of several VOCs in the population, which could have implications for transmissibility and vaccine efficacy. Methods: Between February and May 2021, SARS-CoV-2 genomes were sequenced using the Oxford nanopore MinION method and the respective genome diversity was elucidated. Phylogenetic analysis was performed and genomes were classified using pangolin lineages. Results: The results highlighted an increase (46%) in the alpha VOC (B.1.1.7) in the Gabonese population over the study period. In addition, an increase (31%) in the B.1.1.318 lineage, which is associated with high transmission and impaired vaccine efficacy (D614G+E484K+Y144del), was detected. Conclusion: With the second wave ongoing, these findings highlight the need for surveillance of the SARS-CoV-2 genome in the Republic of Gabon and should provide useful guidance to policymakers in selecting an appropriate vaccine for this population. |
| format |
article |
| author |
Gédéon Prince Manouana Moustapha Nzamba Maloum Rodrigue Bikangui Sam O'neilla Oye Bingono Georgelin Ondo Nguema Josiane Yabo Honkpehedji Elie Gide Rossatanga Samira Zoa-Assoumou Srinivas Reddy Pallerla Sivaramakrishna Rachakonda Armel Ndong Mintsa Jean-Bernard Lekana-Douki Joël-Fleury Djoba Siawaya Steffen Borrmann Peter Gottfried Kremsner Bertrand Lell Thirumalaisamy P. Velavan Ayola Akim Adegnika |
| author_facet |
Gédéon Prince Manouana Moustapha Nzamba Maloum Rodrigue Bikangui Sam O'neilla Oye Bingono Georgelin Ondo Nguema Josiane Yabo Honkpehedji Elie Gide Rossatanga Samira Zoa-Assoumou Srinivas Reddy Pallerla Sivaramakrishna Rachakonda Armel Ndong Mintsa Jean-Bernard Lekana-Douki Joël-Fleury Djoba Siawaya Steffen Borrmann Peter Gottfried Kremsner Bertrand Lell Thirumalaisamy P. Velavan Ayola Akim Adegnika |
| author_sort |
Gédéon Prince Manouana |
| title |
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon |
| title_short |
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon |
| title_full |
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon |
| title_fullStr |
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon |
| title_full_unstemmed |
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon |
| title_sort |
emergence of b.1.1.318 sars-cov-2 viral lineage and high incidence of alpha b.1.1.7 variant of concern in the republic of gabon |
| publisher |
Elsevier |
| publishDate |
2022 |
| url |
https://doaj.org/article/eb05be132adc4cef94d189bea0a38b96 |
| work_keys_str_mv |
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