Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age

Introduction: the best therapeutic option for the management of craniopharyngioma in younger children remains controversial, ranging from complete surgical resection, partial surgical resection associated with radiotherapy and application of chemotherapeutic agents such as bleomycin and interferon-a...

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Autores principales:	Jose Roberto Tude Melo, Felipe Reynan Paiva Vieira Santos, Igor Campos da Silva, José Henrique Silva Barreto
Formato:	article
Lenguaje:	EN
Publicado:	Brazilian Society for Pediatric Neurosurgery 2021
Materias:	neurosurgery pharmacological treatment chemotherapy brain tumors Pediatrics RJ1-570 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/eb05f38528364cf0bd1db882e1b523e0
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spelling	oai:doaj.org-article:eb05f38528364cf0bd1db882e1b523e02021-11-23T21:46:36ZInterferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age2675-362610.46900/apn.v3i2(May-August).66https://doaj.org/article/eb05f38528364cf0bd1db882e1b523e02021-02-01T00:00:00Zhttps://www.archpedneurosurg.com.br/pkp/index.php/sbnped2019/article/view/66https://doaj.org/toc/2675-3626Introduction: the best therapeutic option for the management of craniopharyngioma in younger children remains controversial, ranging from complete surgical resection, partial surgical resection associated with radiotherapy and application of chemotherapeutic agents such as bleomycin and interferon-alfa. Objective: to verify the response to treatment with interferon-alfa via Ommaya reservoir in a group of children under 5 years of age with diagnosis of cystic craniopharyngioma. Methods: description of a case series through consecutive review of medical records of children under 5 years of age diagnosed with cystic adamantinomatous craniopharyngioma who had an Ommaya reservoir catheter surgically implanted for intratumoral application of interferon-?. Results: seven children aged 18 to 60 months (median 46 months) with the abovementioned diagnosis and treated with interferon-alfa between 2010 and 2019, according to a pre-established protocol, were identified. A reduction in tumor volume, ranging from 88 to 100%, one year after the end of treatment was observed in the study sample. There were no complications that justified the interruption or modification of the established therapy. Conclusion: in all the cases evaluated of children less than 5 years of age with predominantly cystic adamantinomatous craniopharyngioma we observed a reduction of tumor volume on magnetic resonance imaging one year after the end of treatment with interferon-alfa.Jose Roberto Tude MeloFelipe Reynan Paiva Vieira SantosIgor Campos da SilvaJosé Henrique Silva BarretoBrazilian Society for Pediatric Neurosurgeryarticleneurosurgerypharmacological treatmentchemotherapybrain tumorsPediatricsRJ1-570SurgeryRD1-811ENArchives of Pediatric Neurosurgery, Vol 3, Iss 2(May-August), Pp e662021-e662021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurosurgery pharmacological treatment chemotherapy brain tumors Pediatrics RJ1-570 Surgery RD1-811
spellingShingle	neurosurgery pharmacological treatment chemotherapy brain tumors Pediatrics RJ1-570 Surgery RD1-811 Jose Roberto Tude Melo Felipe Reynan Paiva Vieira Santos Igor Campos da Silva José Henrique Silva Barreto Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age
description	Introduction: the best therapeutic option for the management of craniopharyngioma in younger children remains controversial, ranging from complete surgical resection, partial surgical resection associated with radiotherapy and application of chemotherapeutic agents such as bleomycin and interferon-alfa. Objective: to verify the response to treatment with interferon-alfa via Ommaya reservoir in a group of children under 5 years of age with diagnosis of cystic craniopharyngioma. Methods: description of a case series through consecutive review of medical records of children under 5 years of age diagnosed with cystic adamantinomatous craniopharyngioma who had an Ommaya reservoir catheter surgically implanted for intratumoral application of interferon-?. Results: seven children aged 18 to 60 months (median 46 months) with the abovementioned diagnosis and treated with interferon-alfa between 2010 and 2019, according to a pre-established protocol, were identified. A reduction in tumor volume, ranging from 88 to 100%, one year after the end of treatment was observed in the study sample. There were no complications that justified the interruption or modification of the established therapy. Conclusion: in all the cases evaluated of children less than 5 years of age with predominantly cystic adamantinomatous craniopharyngioma we observed a reduction of tumor volume on magnetic resonance imaging one year after the end of treatment with interferon-alfa.
format	article
author	Jose Roberto Tude Melo Felipe Reynan Paiva Vieira Santos Igor Campos da Silva José Henrique Silva Barreto
author_facet	Jose Roberto Tude Melo Felipe Reynan Paiva Vieira Santos Igor Campos da Silva José Henrique Silva Barreto
author_sort	Jose Roberto Tude Melo
title	Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age
title_short	Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age
title_full	Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age
title_fullStr	Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age
title_full_unstemmed	Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age
title_sort	interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age
publisher	Brazilian Society for Pediatric Neurosurgery
publishDate	2021
url	https://doaj.org/article/eb05f38528364cf0bd1db882e1b523e0
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Interferon-alfa in the management of cystic craniopharyngioma in children under 5 years of age

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