Multiple sclerosis and CCSVI: a population-based case control study.

<h4>Background</h4>Chronic cerebrospinal venous insufficiency (CCSVI) has been associated to multiple sclerosis (MS).<h4>Objective</h4>To evaluate the possible association between CCSVI and MS, using a population-based control design.<h4>Methods</h4>A random cohor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesco Patti, Alessandra Nicoletti, Carmela Leone, Silvia Messina, Emanuele D'Amico, Salvatore Lo Fermo, Vincenza Paradisi, Elisa Bruno, Graziella Quattrocchi, Pierfrancesco Veroux, Luigi Di Pino, Luca Costanzo, Mario Zappia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb0b721496014156b49e28a85b707aef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb0b721496014156b49e28a85b707aef
record_format	dspace
spelling	oai:doaj.org-article:eb0b721496014156b49e28a85b707aef2021-11-18T07:09:53ZMultiple sclerosis and CCSVI: a population-based case control study.1932-620310.1371/journal.pone.0041227https://doaj.org/article/eb0b721496014156b49e28a85b707aef2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22870210/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Chronic cerebrospinal venous insufficiency (CCSVI) has been associated to multiple sclerosis (MS).<h4>Objective</h4>To evaluate the possible association between CCSVI and MS, using a population-based control design.<h4>Methods</h4>A random cohort of 148 incident MS patients were enrolled in the study. We have also studied 20 patients with clinically isolated syndrome (CIS), 40 patients with other neurological diseases (OND), and 172 healthy controls. Transcranial (TCC) and Echo Color Doppler (ECD) were carried out in 380 subjects. A subject was considered CCSVI positive if ≥2 venous hemodynamic criteria were fulfilled.<h4>Results</h4>CCSVI was present in 28 (18.9%) of the MS patients, in 2 (10%) of CIS patients, in 11 (6.4%) of the controls, and in 2 (5%) of the OND patients. A significant association between MS and CCSVI was found with an odds ratio of 3.41 (95% confidence interval 1.63-7.13; p = 0.001). CCSVI was significantly more frequent among MS subjects with a disease duration longer than 144 months (26.1% versus 12.6% of patients with duration shorter than 144 months; p = 0.03) and among patients with secondary progressive (SP) and primary progressive (PP) forms (30.2% and 29.4, respectively) than in patients with relapsing remitting (RR) MS (14.3%). A stronger association was found considering SP and PP forms (age adjusted OR = 4.7; 95% CI 1.83-12.0, p = 0.001); the association was weaker with the RR patients (age adjusted OR = 2.58; 95%CI 1.12-5.92; p = 0.02) or not significant in CIS group (age adjusted OR = 2.04; 95%CI 0.40-10.3; p = 0.4).<h4>Conclusions</h4>A higher frequency of CCSVI has been found in MS patients; it was more evident in patients with advanced MS, suggesting that CCSVI could be related to MS disability.Francesco PattiAlessandra NicolettiCarmela LeoneSilvia MessinaEmanuele D'AmicoSalvatore Lo FermoVincenza ParadisiElisa BrunoGraziella QuattrocchiPierfrancesco VerouxLuigi Di PinoLuca CostanzoMario ZappiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e41227 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francesco Patti Alessandra Nicoletti Carmela Leone Silvia Messina Emanuele D'Amico Salvatore Lo Fermo Vincenza Paradisi Elisa Bruno Graziella Quattrocchi Pierfrancesco Veroux Luigi Di Pino Luca Costanzo Mario Zappia Multiple sclerosis and CCSVI: a population-based case control study.
description	<h4>Background</h4>Chronic cerebrospinal venous insufficiency (CCSVI) has been associated to multiple sclerosis (MS).<h4>Objective</h4>To evaluate the possible association between CCSVI and MS, using a population-based control design.<h4>Methods</h4>A random cohort of 148 incident MS patients were enrolled in the study. We have also studied 20 patients with clinically isolated syndrome (CIS), 40 patients with other neurological diseases (OND), and 172 healthy controls. Transcranial (TCC) and Echo Color Doppler (ECD) were carried out in 380 subjects. A subject was considered CCSVI positive if ≥2 venous hemodynamic criteria were fulfilled.<h4>Results</h4>CCSVI was present in 28 (18.9%) of the MS patients, in 2 (10%) of CIS patients, in 11 (6.4%) of the controls, and in 2 (5%) of the OND patients. A significant association between MS and CCSVI was found with an odds ratio of 3.41 (95% confidence interval 1.63-7.13; p = 0.001). CCSVI was significantly more frequent among MS subjects with a disease duration longer than 144 months (26.1% versus 12.6% of patients with duration shorter than 144 months; p = 0.03) and among patients with secondary progressive (SP) and primary progressive (PP) forms (30.2% and 29.4, respectively) than in patients with relapsing remitting (RR) MS (14.3%). A stronger association was found considering SP and PP forms (age adjusted OR = 4.7; 95% CI 1.83-12.0, p = 0.001); the association was weaker with the RR patients (age adjusted OR = 2.58; 95%CI 1.12-5.92; p = 0.02) or not significant in CIS group (age adjusted OR = 2.04; 95%CI 0.40-10.3; p = 0.4).<h4>Conclusions</h4>A higher frequency of CCSVI has been found in MS patients; it was more evident in patients with advanced MS, suggesting that CCSVI could be related to MS disability.
format	article
author	Francesco Patti Alessandra Nicoletti Carmela Leone Silvia Messina Emanuele D'Amico Salvatore Lo Fermo Vincenza Paradisi Elisa Bruno Graziella Quattrocchi Pierfrancesco Veroux Luigi Di Pino Luca Costanzo Mario Zappia
author_facet	Francesco Patti Alessandra Nicoletti Carmela Leone Silvia Messina Emanuele D'Amico Salvatore Lo Fermo Vincenza Paradisi Elisa Bruno Graziella Quattrocchi Pierfrancesco Veroux Luigi Di Pino Luca Costanzo Mario Zappia
author_sort	Francesco Patti
title	Multiple sclerosis and CCSVI: a population-based case control study.
title_short	Multiple sclerosis and CCSVI: a population-based case control study.
title_full	Multiple sclerosis and CCSVI: a population-based case control study.
title_fullStr	Multiple sclerosis and CCSVI: a population-based case control study.
title_full_unstemmed	Multiple sclerosis and CCSVI: a population-based case control study.
title_sort	multiple sclerosis and ccsvi: a population-based case control study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/eb0b721496014156b49e28a85b707aef
work_keys_str_mv	AT francescopatti multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT alessandranicoletti multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT carmelaleone multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT silviamessina multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT emanueledamico multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT salvatorelofermo multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT vincenzaparadisi multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT elisabruno multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT graziellaquattrocchi multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT pierfrancescoveroux multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT luigidipino multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT lucacostanzo multiplesclerosisandccsviapopulationbasedcasecontrolstudy AT mariozappia multiplesclerosisandccsviapopulationbasedcasecontrolstudy
_version_	1718423888403103744

Multiple sclerosis and CCSVI: a population-based case control study.

Ejemplares similares