USP11 controls R-loops by regulating senataxin proteostasis

DNA:RNA hybrids (R-loops) are products of transcription that impact genome integrity and gene expression. Here the authors reveal a mechanism for regulating R-loops in a ubiquitination-dependent manner controlled by the activities of USP11 and KEAP1

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Autores principales:	Mateusz Jurga, Arwa A. Abugable, Alastair S. H. Goldman, Sherif F. El-Khamisy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb0bfd4248dd4385a038034986f146a7
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spelling	oai:doaj.org-article:eb0bfd4248dd4385a038034986f146a72021-12-02T17:23:40ZUSP11 controls R-loops by regulating senataxin proteostasis10.1038/s41467-021-25459-w2041-1723https://doaj.org/article/eb0bfd4248dd4385a038034986f146a72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25459-whttps://doaj.org/toc/2041-1723DNA:RNA hybrids (R-loops) are products of transcription that impact genome integrity and gene expression. Here the authors reveal a mechanism for regulating R-loops in a ubiquitination-dependent manner controlled by the activities of USP11 and KEAP1Mateusz JurgaArwa A. AbugableAlastair S. H. GoldmanSherif F. El-KhamisyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mateusz Jurga Arwa A. Abugable Alastair S. H. Goldman Sherif F. El-Khamisy USP11 controls R-loops by regulating senataxin proteostasis
description	DNA:RNA hybrids (R-loops) are products of transcription that impact genome integrity and gene expression. Here the authors reveal a mechanism for regulating R-loops in a ubiquitination-dependent manner controlled by the activities of USP11 and KEAP1
format	article
author	Mateusz Jurga Arwa A. Abugable Alastair S. H. Goldman Sherif F. El-Khamisy
author_facet	Mateusz Jurga Arwa A. Abugable Alastair S. H. Goldman Sherif F. El-Khamisy
author_sort	Mateusz Jurga
title	USP11 controls R-loops by regulating senataxin proteostasis
title_short	USP11 controls R-loops by regulating senataxin proteostasis
title_full	USP11 controls R-loops by regulating senataxin proteostasis
title_fullStr	USP11 controls R-loops by regulating senataxin proteostasis
title_full_unstemmed	USP11 controls R-loops by regulating senataxin proteostasis
title_sort	usp11 controls r-loops by regulating senataxin proteostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb0bfd4248dd4385a038034986f146a7
work_keys_str_mv	AT mateuszjurga usp11controlsrloopsbyregulatingsenataxinproteostasis AT arwaaabugable usp11controlsrloopsbyregulatingsenataxinproteostasis AT alastairshgoldman usp11controlsrloopsbyregulatingsenataxinproteostasis AT sheriffelkhamisy usp11controlsrloopsbyregulatingsenataxinproteostasis
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USP11 controls R-loops by regulating senataxin proteostasis

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