Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway
While the regulating mechanisms of slow myofibers have been gradually explored, there are currently a lack of effective means to increase slow myofibers proportion. Here, we have showed that luteolin could markedly improve endurance exercise performance and increase body oxygen consumption of mice,...
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Elsevier
2022
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oai:doaj.org-article:eb0cd06136fc4791b4db38bef80e953e2021-12-04T04:33:27ZLuteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway1756-464610.1016/j.jff.2021.104876https://doaj.org/article/eb0cd06136fc4791b4db38bef80e953e2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005259https://doaj.org/toc/1756-4646While the regulating mechanisms of slow myofibers have been gradually explored, there are currently a lack of effective means to increase slow myofibers proportion. Here, we have showed that luteolin could markedly improve endurance exercise performance and increase body oxygen consumption of mice, and activate aerobic enzyme activity and slow myofibers related genes and proteins expression in mice’s skeletal muscle. Meanwhile, folliculin (FLCN)-AMP-activated protein kinase (AMPK) -peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) pathway was activated by treatment luteolin in the tissues. Furthermore, by in vitro investigation and FLCN lentivirus infection, we have found that the over-expression of FLCN significantly reduces the effects of luteolin on slow myofibers expression and AMPK-PGC-1α axis activation. Together, our results indicate that luteolin can increase the proportion of slow myofibers probably by FLCN-AMPK-PGC-1α pathway. These findings provide a novel approach to increase slow muscle fibers proportion and improve skeletal muscle fitness.Peiyuan LiRuilin XuYanfei ShiXiaoyang ShiXinyuan ZhangJinjie LiGuangning KouElsevierarticleSkeletal muscleSlow fibersLuteolinFLCNNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 88, Iss , Pp 104876- (2022) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Skeletal muscle Slow fibers Luteolin FLCN Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
Skeletal muscle Slow fibers Luteolin FLCN Nutrition. Foods and food supply TX341-641 Peiyuan Li Ruilin Xu Yanfei Shi Xiaoyang Shi Xinyuan Zhang Jinjie Li Guangning Kou Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway |
| description |
While the regulating mechanisms of slow myofibers have been gradually explored, there are currently a lack of effective means to increase slow myofibers proportion. Here, we have showed that luteolin could markedly improve endurance exercise performance and increase body oxygen consumption of mice, and activate aerobic enzyme activity and slow myofibers related genes and proteins expression in mice’s skeletal muscle. Meanwhile, folliculin (FLCN)-AMP-activated protein kinase (AMPK) -peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) pathway was activated by treatment luteolin in the tissues. Furthermore, by in vitro investigation and FLCN lentivirus infection, we have found that the over-expression of FLCN significantly reduces the effects of luteolin on slow myofibers expression and AMPK-PGC-1α axis activation. Together, our results indicate that luteolin can increase the proportion of slow myofibers probably by FLCN-AMPK-PGC-1α pathway. These findings provide a novel approach to increase slow muscle fibers proportion and improve skeletal muscle fitness. |
| format |
article |
| author |
Peiyuan Li Ruilin Xu Yanfei Shi Xiaoyang Shi Xinyuan Zhang Jinjie Li Guangning Kou |
| author_facet |
Peiyuan Li Ruilin Xu Yanfei Shi Xiaoyang Shi Xinyuan Zhang Jinjie Li Guangning Kou |
| author_sort |
Peiyuan Li |
| title |
Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway |
| title_short |
Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway |
| title_full |
Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway |
| title_fullStr |
Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway |
| title_full_unstemmed |
Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway |
| title_sort |
luteolin increases slow muscle fibers via flcn-ampk-pgc-1α signaling pathway |
| publisher |
Elsevier |
| publishDate |
2022 |
| url |
https://doaj.org/article/eb0cd06136fc4791b4db38bef80e953e |
| work_keys_str_mv |
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