Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and found that the sensitivity to MEK inhibitors varied drastically between these cell lines...

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Autores principales: Mathurin Dorel, Bertram Klinger, Tommaso Mari, Joern Toedling, Eric Blanc, Clemens Messerschmidt, Michal Nadler-Holly, Matthias Ziehm, Anja Sieber, Falk Hertwig, Dieter Beule, Angelika Eggert, Johannes H. Schulte, Matthias Selbach, Nils Blüthgen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/eb0d4b5da0ad4179bece23442265192b
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