Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion

Abstract The spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a population of glutamatergic neurons, termed Hb9 interneurons, contributes to locomotor rhythmogenesis. These neurons were identified by their expr...

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Autores principales:	Lina M. Koronfel, Kevin C. Kanning, Angelita Alcos, Christopher E. Henderson, Robert M. Brownstone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb0df315d79d48c68e4251d3b6cebe32
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spelling	oai:doaj.org-article:eb0df315d79d48c68e4251d3b6cebe322021-12-02T16:35:37ZElimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion10.1038/s41598-021-95143-y2045-2322https://doaj.org/article/eb0df315d79d48c68e4251d3b6cebe322021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95143-yhttps://doaj.org/toc/2045-2322Abstract The spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a population of glutamatergic neurons, termed Hb9 interneurons, contributes to locomotor rhythmogenesis. These neurons were identified by their expression of the homeobox gene, Hb9, which is also expressed in motor neurons. We developed a mouse line in which Cre recombinase activity is inducible in neurons expressing Hb9. We then used this line to eliminate vesicular glutamate transporter 2 from Hb9 interneurons, and found that there were no deficits in treadmill locomotion. We conclude that glutamatergic neurotransmission by Hb9 interneurons is not required for locomotor behaviour. The role of these neurons in neural circuits remains elusive.Lina M. KoronfelKevin C. KanningAngelita AlcosChristopher E. HendersonRobert M. BrownstoneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lina M. Koronfel Kevin C. Kanning Angelita Alcos Christopher E. Henderson Robert M. Brownstone Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion
description	Abstract The spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a population of glutamatergic neurons, termed Hb9 interneurons, contributes to locomotor rhythmogenesis. These neurons were identified by their expression of the homeobox gene, Hb9, which is also expressed in motor neurons. We developed a mouse line in which Cre recombinase activity is inducible in neurons expressing Hb9. We then used this line to eliminate vesicular glutamate transporter 2 from Hb9 interneurons, and found that there were no deficits in treadmill locomotion. We conclude that glutamatergic neurotransmission by Hb9 interneurons is not required for locomotor behaviour. The role of these neurons in neural circuits remains elusive.
format	article
author	Lina M. Koronfel Kevin C. Kanning Angelita Alcos Christopher E. Henderson Robert M. Brownstone
author_facet	Lina M. Koronfel Kevin C. Kanning Angelita Alcos Christopher E. Henderson Robert M. Brownstone
author_sort	Lina M. Koronfel
title	Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion
title_short	Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion
title_full	Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion
title_fullStr	Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion
title_full_unstemmed	Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion
title_sort	elimination of glutamatergic transmission from hb9 interneurons does not impact treadmill locomotion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb0df315d79d48c68e4251d3b6cebe32
work_keys_str_mv	AT linamkoronfel eliminationofglutamatergictransmissionfromhb9interneuronsdoesnotimpacttreadmilllocomotion AT kevinckanning eliminationofglutamatergictransmissionfromhb9interneuronsdoesnotimpacttreadmilllocomotion AT angelitaalcos eliminationofglutamatergictransmissionfromhb9interneuronsdoesnotimpacttreadmilllocomotion AT christopherehenderson eliminationofglutamatergictransmissionfromhb9interneuronsdoesnotimpacttreadmilllocomotion AT robertmbrownstone eliminationofglutamatergictransmissionfromhb9interneuronsdoesnotimpacttreadmilllocomotion
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Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion

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