Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.

<h4>Background</h4>There is little consensus, and minimal evidence, regarding the age at which to stop cervical screening. We studied the association between screening at age 50-64 y and cervical cancer at age 65-83 y.<h4>Methods and findings</h4>Cases were women (n = 1,341)...

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Autores principales:	Alejandra Castañón, Rebecca Landy, Jack Cuzick, Peter Sasieni
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/eb116b52f12e41ea924ed58703080786
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spelling	oai:doaj.org-article:eb116b52f12e41ea924ed587030807862021-11-18T05:43:00ZCervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.1549-12771549-167610.1371/journal.pmed.1001585https://doaj.org/article/eb116b52f12e41ea924ed587030807862014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24453946/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676<h4>Background</h4>There is little consensus, and minimal evidence, regarding the age at which to stop cervical screening. We studied the association between screening at age 50-64 y and cervical cancer at age 65-83 y.<h4>Methods and findings</h4>Cases were women (n = 1,341) diagnosed with cervical cancer at age 65-83 y between 1 April 2007 and 31 March 2012 in England and Wales; age-matched controls (n = 2,646) were randomly selected from population registers. Screening details from 1988 onwards were extracted from national databases. We calculated the odds ratios (OR) for different screening histories and subsequent cervical cancer. Women with adequate negative screening at age 65 y (288 cases, 1,395 controls) were at lowest risk of cervical cancer (20-y risk: 8 cancers per 10,000 women) compared with those (532 cases, 429 controls) not screened at age 50-64 y (20-y risk: 49 cancers per 10,000 women, with OR = 0.16, 95% CI 0.13-0.19). ORs depended on the age mix of women because of the weakening association with time since last screen: OR = 0.11, 95% CI 0.08-0.14 at 2.5 to 7.5 y since last screen; OR = 0.27, 95% CI 0.20-0.36 at 12.5 to 17.5 y since last screen. Screening at least every 5.5 y between the ages 50 and 64 y was associated with a 75% lower risk of cervical cancer between the ages 65 and 79 y (OR = 0.25, 95% CI 0.21-0.30), and the attributable risk was such that in the absence of screening, cervical cancer rates in women aged 65+ would have been 2.4 (95% CI 2.1-2.7) times higher. In women aged 80-83 y the association was weaker (OR = 0.49, 95% CI 0.28-0.83) than in those aged 65-69 y (OR = 0.12, 95% CI 0.09-0.17). This study was limited by an absence of data on confounding factors; additionally, findings based on cytology may not generalise to human papillomavirus testing.<h4>Conclusions</h4>Women with adequate negative screening at age 50-64 y had one-sixth of the risk of cervical cancer at age 65-83 y compared with women who were not screened. Stopping screening between ages 60 and 69 y in women with adequate negative screening seems sensible, but further screening may be justifiable as life expectancy increases.Alejandra CastañónRebecca LandyJack CuzickPeter SasieniPublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 11, Iss 1, p e1001585 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Alejandra Castañón Rebecca Landy Jack Cuzick Peter Sasieni Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.
description	<h4>Background</h4>There is little consensus, and minimal evidence, regarding the age at which to stop cervical screening. We studied the association between screening at age 50-64 y and cervical cancer at age 65-83 y.<h4>Methods and findings</h4>Cases were women (n = 1,341) diagnosed with cervical cancer at age 65-83 y between 1 April 2007 and 31 March 2012 in England and Wales; age-matched controls (n = 2,646) were randomly selected from population registers. Screening details from 1988 onwards were extracted from national databases. We calculated the odds ratios (OR) for different screening histories and subsequent cervical cancer. Women with adequate negative screening at age 65 y (288 cases, 1,395 controls) were at lowest risk of cervical cancer (20-y risk: 8 cancers per 10,000 women) compared with those (532 cases, 429 controls) not screened at age 50-64 y (20-y risk: 49 cancers per 10,000 women, with OR = 0.16, 95% CI 0.13-0.19). ORs depended on the age mix of women because of the weakening association with time since last screen: OR = 0.11, 95% CI 0.08-0.14 at 2.5 to 7.5 y since last screen; OR = 0.27, 95% CI 0.20-0.36 at 12.5 to 17.5 y since last screen. Screening at least every 5.5 y between the ages 50 and 64 y was associated with a 75% lower risk of cervical cancer between the ages 65 and 79 y (OR = 0.25, 95% CI 0.21-0.30), and the attributable risk was such that in the absence of screening, cervical cancer rates in women aged 65+ would have been 2.4 (95% CI 2.1-2.7) times higher. In women aged 80-83 y the association was weaker (OR = 0.49, 95% CI 0.28-0.83) than in those aged 65-69 y (OR = 0.12, 95% CI 0.09-0.17). This study was limited by an absence of data on confounding factors; additionally, findings based on cytology may not generalise to human papillomavirus testing.<h4>Conclusions</h4>Women with adequate negative screening at age 50-64 y had one-sixth of the risk of cervical cancer at age 65-83 y compared with women who were not screened. Stopping screening between ages 60 and 69 y in women with adequate negative screening seems sensible, but further screening may be justifiable as life expectancy increases.
format	article
author	Alejandra Castañón Rebecca Landy Jack Cuzick Peter Sasieni
author_facet	Alejandra Castañón Rebecca Landy Jack Cuzick Peter Sasieni
author_sort	Alejandra Castañón
title	Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.
title_short	Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.
title_full	Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.
title_fullStr	Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.
title_full_unstemmed	Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.
title_sort	cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/eb116b52f12e41ea924ed58703080786
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Cervical screening at age 50-64 years and the risk of cervical cancer at age 65 years and older: population-based case control study.

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