Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease

Background: Deep Brain Stimulation (DBS) of the subthalamic nucleus or globus pallidus internus is used to treat the motor symptoms of Parkinson's disease. The former can worsen impulsive and compulsive behaviors after controlling for the reduction of dopaminergic medications. However, the effe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Parkinson's disease Deep brain stimulation Impulsivity Globus pallidus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/eb126600740946189c2c0bcbc1641d29
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb126600740946189c2c0bcbc1641d29
record_format	dspace
spelling	oai:doaj.org-article:eb126600740946189c2c0bcbc1641d292021-11-10T04:22:38ZDeep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease1935-861X10.1016/j.brs.2021.11.006https://doaj.org/article/eb126600740946189c2c0bcbc1641d292022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1935861X21008044https://doaj.org/toc/1935-861XBackground: Deep Brain Stimulation (DBS) of the subthalamic nucleus or globus pallidus internus is used to treat the motor symptoms of Parkinson's disease. The former can worsen impulsive and compulsive behaviors after controlling for the reduction of dopaminergic medications. However, the effect of pallidal DBS on such behaviors in PD patients is less clear.Objective/Hypothesis: We hypothesized that greater stimulation spread to the pallidum with prefrontal connectivity would reduce motor impulsivity. Methods: Seven Parkinson's patients with stable globus pallidus internus DBS settings for 3 months, disease duration of 13 ± 1.3 years, and Montreal Cognitive Assessment of 26.8 ± 1.1 each had two stimulation settings defined based on reconstructions of lead placement and volume of tissue activation targeting either a dorsal or ventral position along the DBS electrode but still within the globus pallidus internus. Subjects performed a stop signal reaction time task with the DBS turned off vs. on in each of the defined stimulation settings, which was correlated with the degree of stimulation effect on pallidal subregions. Results: A shorter distance between the volume of tissue activation and the right prefrontally-connected GPi correlated with less impulsivity on the stop signal reaction time task (r = 0.69, p < 0.05). Greater volume of tissue activation overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity. Conclusion: These data can be leveraged to optimize DBS programming in PD patients with problematic impulsivity or in other disorders involving impulsive behaviors such as substance use disorders.Khaled MoussawiMin Jae KimSydney BaybayanMyles WoodKelly A. MillsElsevierarticleParkinson's diseaseDeep brain stimulationImpulsivityGlobus pallidusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Stimulation, Vol 15, Iss 1, Pp 23-31 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson's disease Deep brain stimulation Impulsivity Globus pallidus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson's disease Deep brain stimulation Impulsivity Globus pallidus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Khaled Moussawi Min Jae Kim Sydney Baybayan Myles Wood Kelly A. Mills Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease
description	Background: Deep Brain Stimulation (DBS) of the subthalamic nucleus or globus pallidus internus is used to treat the motor symptoms of Parkinson's disease. The former can worsen impulsive and compulsive behaviors after controlling for the reduction of dopaminergic medications. However, the effect of pallidal DBS on such behaviors in PD patients is less clear.Objective/Hypothesis: We hypothesized that greater stimulation spread to the pallidum with prefrontal connectivity would reduce motor impulsivity. Methods: Seven Parkinson's patients with stable globus pallidus internus DBS settings for 3 months, disease duration of 13 ± 1.3 years, and Montreal Cognitive Assessment of 26.8 ± 1.1 each had two stimulation settings defined based on reconstructions of lead placement and volume of tissue activation targeting either a dorsal or ventral position along the DBS electrode but still within the globus pallidus internus. Subjects performed a stop signal reaction time task with the DBS turned off vs. on in each of the defined stimulation settings, which was correlated with the degree of stimulation effect on pallidal subregions. Results: A shorter distance between the volume of tissue activation and the right prefrontally-connected GPi correlated with less impulsivity on the stop signal reaction time task (r = 0.69, p < 0.05). Greater volume of tissue activation overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity. Conclusion: These data can be leveraged to optimize DBS programming in PD patients with problematic impulsivity or in other disorders involving impulsive behaviors such as substance use disorders.
format	article
author	Khaled Moussawi Min Jae Kim Sydney Baybayan Myles Wood Kelly A. Mills
author_facet	Khaled Moussawi Min Jae Kim Sydney Baybayan Myles Wood Kelly A. Mills
author_sort	Khaled Moussawi
title	Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease
title_short	Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease
title_full	Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease
title_fullStr	Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease
title_full_unstemmed	Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease
title_sort	deep brain stimulation effect on anterior pallidum reduces motor impulsivity in parkinson's disease
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/eb126600740946189c2c0bcbc1641d29
work_keys_str_mv	AT khaledmoussawi deepbrainstimulationeffectonanteriorpallidumreducesmotorimpulsivityinparkinsonsdisease AT minjaekim deepbrainstimulationeffectonanteriorpallidumreducesmotorimpulsivityinparkinsonsdisease AT sydneybaybayan deepbrainstimulationeffectonanteriorpallidumreducesmotorimpulsivityinparkinsonsdisease AT myleswood deepbrainstimulationeffectonanteriorpallidumreducesmotorimpulsivityinparkinsonsdisease AT kellyamills deepbrainstimulationeffectonanteriorpallidumreducesmotorimpulsivityinparkinsonsdisease
_version_	1718440705213333504

Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease

Ejemplares similares