New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms...

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Autores principales:	Denis N. Chausov, Dmitriy E. Burmistrov, Alexander D. Kurilov, Nikolai F. Bunkin, Maxim E. Astashev, Alexander V. Simakin, Maria V. Vedunova, Sergey V. Gudkov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ZnO nanoparticles borosiloxane antibacterial agents composite materials Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/eb14a6801cde4805a33ac6ac72bfc8ad
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spelling	oai:doaj.org-article:eb14a6801cde4805a33ac6ac72bfc8ad2021-11-11T17:51:21ZNew Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells10.3390/ma142162811996-1944https://doaj.org/article/eb14a6801cde4805a33ac6ac72bfc8ad2021-10-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6281https://doaj.org/toc/1996-1944The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of <i>E. coli</i> bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.Denis N. ChausovDmitriy E. BurmistrovAlexander D. KurilovNikolai F. BunkinMaxim E. AstashevAlexander V. SimakinMaria V. VedunovaSergey V. GudkovMDPI AGarticleZnO nanoparticlesborosiloxaneantibacterial agentscomposite materialsTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6281, p 6281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ZnO nanoparticles borosiloxane antibacterial agents composite materials Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	ZnO nanoparticles borosiloxane antibacterial agents composite materials Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Denis N. Chausov Dmitriy E. Burmistrov Alexander D. Kurilov Nikolai F. Bunkin Maxim E. Astashev Alexander V. Simakin Maria V. Vedunova Sergey V. Gudkov New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
description	The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of <i>E. coli</i> bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.
format	article
author	Denis N. Chausov Dmitriy E. Burmistrov Alexander D. Kurilov Nikolai F. Bunkin Maxim E. Astashev Alexander V. Simakin Maria V. Vedunova Sergey V. Gudkov
author_facet	Denis N. Chausov Dmitriy E. Burmistrov Alexander D. Kurilov Nikolai F. Bunkin Maxim E. Astashev Alexander V. Simakin Maria V. Vedunova Sergey V. Gudkov
author_sort	Denis N. Chausov
title	New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_short	New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_full	New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_fullStr	New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_full_unstemmed	New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells
title_sort	new organosilicon composite based on borosiloxane and zinc oxide nanoparticles inhibits bacterial growth, but does not have a toxic effect on the development of animal eukaryotic cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/eb14a6801cde4805a33ac6ac72bfc8ad
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New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

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