Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype

Although Ftx lncRNA has been linked to X-chromosome inactivation, its physiological roles in vivo remain unclear. Here the authors show that deletion of mouse Ftx causes eye abnormalities similar to human microphthalmia in a subset of female mice but rarely in males and provide evidence that Ftx pla...

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Autores principales:	Yusuke Hosoi, Miki Soma, Hirosuke Shiura, Takashi Sado, Hidetoshi Hasuwa, Kuniya Abe, Takashi Kohda, Fumitoshi Ishino, Shin Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb168a2bde444d00baa2da1b1bb42af5
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spelling	oai:doaj.org-article:eb168a2bde444d00baa2da1b1bb42af52021-12-02T14:40:31ZFemale mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype10.1038/s41467-018-06327-62041-1723https://doaj.org/article/eb168a2bde444d00baa2da1b1bb42af52018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06327-6https://doaj.org/toc/2041-1723Although Ftx lncRNA has been linked to X-chromosome inactivation, its physiological roles in vivo remain unclear. Here the authors show that deletion of mouse Ftx causes eye abnormalities similar to human microphthalmia in a subset of female mice but rarely in males and provide evidence that Ftx plays a role in gene silencing on the inactive X chromosome.Yusuke HosoiMiki SomaHirosuke ShiuraTakashi SadoHidetoshi HasuwaKuniya AbeTakashi KohdaFumitoshi IshinoShin KobayashiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Hosoi Miki Soma Hirosuke Shiura Takashi Sado Hidetoshi Hasuwa Kuniya Abe Takashi Kohda Fumitoshi Ishino Shin Kobayashi Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
description	Although Ftx lncRNA has been linked to X-chromosome inactivation, its physiological roles in vivo remain unclear. Here the authors show that deletion of mouse Ftx causes eye abnormalities similar to human microphthalmia in a subset of female mice but rarely in males and provide evidence that Ftx plays a role in gene silencing on the inactive X chromosome.
format	article
author	Yusuke Hosoi Miki Soma Hirosuke Shiura Takashi Sado Hidetoshi Hasuwa Kuniya Abe Takashi Kohda Fumitoshi Ishino Shin Kobayashi
author_facet	Yusuke Hosoi Miki Soma Hirosuke Shiura Takashi Sado Hidetoshi Hasuwa Kuniya Abe Takashi Kohda Fumitoshi Ishino Shin Kobayashi
author_sort	Yusuke Hosoi
title	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_short	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_full	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_fullStr	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_full_unstemmed	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_sort	female mice lacking ftx lncrna exhibit impaired x-chromosome inactivation and a microphthalmia-like phenotype
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eb168a2bde444d00baa2da1b1bb42af5
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Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype

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