Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

Intermittent preventive treatment with dihydroartemisinin-piperaquine (DP) is protective in children against malaria. Here, the authors analyze plasma drug concentration, malaria incidence, and drug resistance markers from a clinical trial in Uganda and determine the optimal DP dosing regimen.

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Bibliographic Details
Main Authors: Erika Wallender, Ali Mohamed Ali, Emma Hughes, Abel Kakuru, Prasanna Jagannathan, Mary Kakuru Muhindo, Bishop Opira, Meghan Whalen, Liusheng Huang, Marvin Duvalsaint, Jenny Legac, Moses R. Kamya, Grant Dorsey, Francesca Aweeka, Philip J. Rosenthal, Rada M. Savic
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/eb16f6a003e14f9781c89f59d68e0072
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Summary:Intermittent preventive treatment with dihydroartemisinin-piperaquine (DP) is protective in children against malaria. Here, the authors analyze plasma drug concentration, malaria incidence, and drug resistance markers from a clinical trial in Uganda and determine the optimal DP dosing regimen.

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