Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

Intermittent preventive treatment with dihydroartemisinin-piperaquine (DP) is protective in children against malaria. Here, the authors analyze plasma drug concentration, malaria incidence, and drug resistance markers from a clinical trial in Uganda and determine the optimal DP dosing regimen.

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Bibliographic Details
Main Authors:	Erika Wallender, Ali Mohamed Ali, Emma Hughes, Abel Kakuru, Prasanna Jagannathan, Mary Kakuru Muhindo, Bishop Opira, Meghan Whalen, Liusheng Huang, Marvin Duvalsaint, Jenny Legac, Moses R. Kamya, Grant Dorsey, Francesca Aweeka, Philip J. Rosenthal, Rada M. Savic
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/eb16f6a003e14f9781c89f59d68e0072
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spelling	oai:doaj.org-article:eb16f6a003e14f9781c89f59d68e00722021-11-21T12:36:31ZIdentifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children10.1038/s41467-021-27051-82041-1723https://doaj.org/article/eb16f6a003e14f9781c89f59d68e00722021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27051-8https://doaj.org/toc/2041-1723Intermittent preventive treatment with dihydroartemisinin-piperaquine (DP) is protective in children against malaria. Here, the authors analyze plasma drug concentration, malaria incidence, and drug resistance markers from a clinical trial in Uganda and determine the optimal DP dosing regimen.Erika WallenderAli Mohamed AliEmma HughesAbel KakuruPrasanna JagannathanMary Kakuru MuhindoBishop OpiraMeghan WhalenLiusheng HuangMarvin DuvalsaintJenny LegacMoses R. KamyaGrant DorseyFrancesca AweekaPhilip J. RosenthalRada M. SavicNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erika Wallender Ali Mohamed Ali Emma Hughes Abel Kakuru Prasanna Jagannathan Mary Kakuru Muhindo Bishop Opira Meghan Whalen Liusheng Huang Marvin Duvalsaint Jenny Legac Moses R. Kamya Grant Dorsey Francesca Aweeka Philip J. Rosenthal Rada M. Savic Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
description	Intermittent preventive treatment with dihydroartemisinin-piperaquine (DP) is protective in children against malaria. Here, the authors analyze plasma drug concentration, malaria incidence, and drug resistance markers from a clinical trial in Uganda and determine the optimal DP dosing regimen.
format	article
author	Erika Wallender Ali Mohamed Ali Emma Hughes Abel Kakuru Prasanna Jagannathan Mary Kakuru Muhindo Bishop Opira Meghan Whalen Liusheng Huang Marvin Duvalsaint Jenny Legac Moses R. Kamya Grant Dorsey Francesca Aweeka Philip J. Rosenthal Rada M. Savic
author_facet	Erika Wallender Ali Mohamed Ali Emma Hughes Abel Kakuru Prasanna Jagannathan Mary Kakuru Muhindo Bishop Opira Meghan Whalen Liusheng Huang Marvin Duvalsaint Jenny Legac Moses R. Kamya Grant Dorsey Francesca Aweeka Philip J. Rosenthal Rada M. Savic
author_sort	Erika Wallender
title	Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
title_short	Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
title_full	Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
title_fullStr	Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
title_full_unstemmed	Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
title_sort	identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young ugandan children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb16f6a003e14f9781c89f59d68e0072
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Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children

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