Induction of HIF-1α by HIV-1 Infection in CD4<sup>+</sup> T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

ABSTRACT Chronic immune activation and inflammation are hallmarks of HIV-1 infection and a major cause of serious non-AIDS events in HIV-1-infected individuals on antiretroviral treatment (ART). Herein, we show that cytosolic double-stranded DNA (dsDNA) generated in infected CD4+ T cells during the...

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Auteurs principaux:	Gabriel Duette, Pehuen Pereyra Gerber, Julia Rubione, Paula S. Perez, Alan L. Landay, Suzanne M. Crowe, Zhaohao Liao, Kenneth W. Witwer, María Pía Holgado, Jimena Salido, Jorge Geffner, Omar Sued, Clovis S. Palmer, Matias Ostrowski
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2018
Sujets:	CD4+ T lymphocyte extracellular vesicles hypoxia-inducible factor 1 alpha inflammation human immunodeficiency virus macrophage Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/eb1accfedd334fa5b0ed56cc2700e7cd
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Induction of HIF-1α by HIV-1 Infection in CD4<sup>+</sup> T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

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