Induction of HIF-1α by HIV-1 Infection in CD4<sup>+</sup> T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

Induction of HIF-1α by HIV-1 Infection in CD4<sup>+</sup> T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

ABSTRACT Chronic immune activation and inflammation are hallmarks of HIV-1 infection and a major cause of serious non-AIDS events in HIV-1-infected individuals on antiretroviral treatment (ART). Herein, we show that cytosolic double-stranded DNA (dsDNA) generated in infected CD4+ T cells during the...

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Bibliographic Details
Main Authors: Gabriel Duette, Pehuen Pereyra Gerber, Julia Rubione, Paula S. Perez, Alan L. Landay, Suzanne M. Crowe, Zhaohao Liao, Kenneth W. Witwer, María Pía Holgado, Jimena Salido, Jorge Geffner, Omar Sued, Clovis S. Palmer, Matias Ostrowski
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
CD4+ T lymphocyte
extracellular vesicles
hypoxia-inducible factor 1 alpha
inflammation
human immunodeficiency virus
macrophage
Microbiology
QR1-502
Online Access:https://doaj.org/article/eb1accfedd334fa5b0ed56cc2700e7cd
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https://doaj.org/article/eb1accfedd334fa5b0ed56cc2700e7cd

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