A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection.
A large proportion of the death toll associated with malaria is a consequence of malaria infection during pregnancy, causing up to 200,000 infant deaths annually. We previously published the first extensive genetic association study of placental malaria infection, and here we extend this analysis co...
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Public Library of Science (PLoS)
2011
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oai:doaj.org-article:eb1c2e79e6bf4d94bdf8a0a91d4987c12021-11-04T06:08:16ZA targeted association study of immunity genes and networks suggests novel associations with placental malaria infection.1932-620310.1371/journal.pone.0024996https://doaj.org/article/eb1c2e79e6bf4d94bdf8a0a91d4987c12011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949827/?tool=EBIhttps://doaj.org/toc/1932-6203A large proportion of the death toll associated with malaria is a consequence of malaria infection during pregnancy, causing up to 200,000 infant deaths annually. We previously published the first extensive genetic association study of placental malaria infection, and here we extend this analysis considerably, investigating genetic variation in over 9,000 SNPs in more than 1,000 genes involved in immunity and inflammation for their involvement in susceptibility to placental malaria infection. We applied a new approach incorporating results from both single gene analysis as well as gene-gene interactions on a protein-protein interaction network. We found suggestive associations of variants in the gene KLRK1 in the single gene analysis, as well as evidence for associations of multiple members of the IL-7/IL-7R signalling cascade in the combined analysis. To our knowledge, this is the first large-scale genetic study on placental malaria infection to date, opening the door for follow-up studies trying to elucidate the genetic basis of this neglected form of malaria.Martin SikoraHafid LaayouniClara MenendezAlfredo MayorAzucena BardajiBetuel SigauqueMihai G NeteaFerran CasalsJaume BertranpetitPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24996 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Martin Sikora Hafid Laayouni Clara Menendez Alfredo Mayor Azucena Bardaji Betuel Sigauque Mihai G Netea Ferran Casals Jaume Bertranpetit A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection. |
| description |
A large proportion of the death toll associated with malaria is a consequence of malaria infection during pregnancy, causing up to 200,000 infant deaths annually. We previously published the first extensive genetic association study of placental malaria infection, and here we extend this analysis considerably, investigating genetic variation in over 9,000 SNPs in more than 1,000 genes involved in immunity and inflammation for their involvement in susceptibility to placental malaria infection. We applied a new approach incorporating results from both single gene analysis as well as gene-gene interactions on a protein-protein interaction network. We found suggestive associations of variants in the gene KLRK1 in the single gene analysis, as well as evidence for associations of multiple members of the IL-7/IL-7R signalling cascade in the combined analysis. To our knowledge, this is the first large-scale genetic study on placental malaria infection to date, opening the door for follow-up studies trying to elucidate the genetic basis of this neglected form of malaria. |
| format |
article |
| author |
Martin Sikora Hafid Laayouni Clara Menendez Alfredo Mayor Azucena Bardaji Betuel Sigauque Mihai G Netea Ferran Casals Jaume Bertranpetit |
| author_facet |
Martin Sikora Hafid Laayouni Clara Menendez Alfredo Mayor Azucena Bardaji Betuel Sigauque Mihai G Netea Ferran Casals Jaume Bertranpetit |
| author_sort |
Martin Sikora |
| title |
A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection. |
| title_short |
A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection. |
| title_full |
A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection. |
| title_fullStr |
A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection. |
| title_full_unstemmed |
A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection. |
| title_sort |
targeted association study of immunity genes and networks suggests novel associations with placental malaria infection. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/eb1c2e79e6bf4d94bdf8a0a91d4987c1 |
| work_keys_str_mv |
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1718445184963837952 |