A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion

The mechanisms by which organisms adapt their growth according to the availability of oxygen are incompletely understood. Here the authors identify the D rosophila fat body as a tissue regulating growth in response to oxygen sensing via a mechanism involving Hph inhibition, HIF1-a activation and ins...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael J. Texada, Anne F. Jørgensen, Christian F. Christensen, Takashi Koyama, Alina Malita, Daniel K. Smith, Dylan F. M. Marple, E. Thomas Danielsen, Sine K. Petersen, Jakob L. Hansen, Kenneth A. Halberg, Kim F. Rewitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb1d36697d6243149fc5a3d90944c202
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb1d36697d6243149fc5a3d90944c202
record_format	dspace
spelling	oai:doaj.org-article:eb1d36697d6243149fc5a3d90944c2022021-12-02T16:58:27ZA fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion10.1038/s41467-019-09943-y2041-1723https://doaj.org/article/eb1d36697d6243149fc5a3d90944c2022019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09943-yhttps://doaj.org/toc/2041-1723The mechanisms by which organisms adapt their growth according to the availability of oxygen are incompletely understood. Here the authors identify the D rosophila fat body as a tissue regulating growth in response to oxygen sensing via a mechanism involving Hph inhibition, HIF1-a activation and insulin secretion.Michael J. TexadaAnne F. JørgensenChristian F. ChristensenTakashi KoyamaAlina MalitaDaniel K. SmithDylan F. M. MarpleE. Thomas DanielsenSine K. PetersenJakob L. HansenKenneth A. HalbergKim F. RewitzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Texada Anne F. Jørgensen Christian F. Christensen Takashi Koyama Alina Malita Daniel K. Smith Dylan F. M. Marple E. Thomas Danielsen Sine K. Petersen Jakob L. Hansen Kenneth A. Halberg Kim F. Rewitz A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
description	The mechanisms by which organisms adapt their growth according to the availability of oxygen are incompletely understood. Here the authors identify the D rosophila fat body as a tissue regulating growth in response to oxygen sensing via a mechanism involving Hph inhibition, HIF1-a activation and insulin secretion.
format	article
author	Michael J. Texada Anne F. Jørgensen Christian F. Christensen Takashi Koyama Alina Malita Daniel K. Smith Dylan F. M. Marple E. Thomas Danielsen Sine K. Petersen Jakob L. Hansen Kenneth A. Halberg Kim F. Rewitz
author_facet	Michael J. Texada Anne F. Jørgensen Christian F. Christensen Takashi Koyama Alina Malita Daniel K. Smith Dylan F. M. Marple E. Thomas Danielsen Sine K. Petersen Jakob L. Hansen Kenneth A. Halberg Kim F. Rewitz
author_sort	Michael J. Texada
title	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_short	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_full	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_fullStr	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_full_unstemmed	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_sort	fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eb1d36697d6243149fc5a3d90944c202
work_keys_str_mv	AT michaeljtexada afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT annefjørgensen afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT christianfchristensen afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT takashikoyama afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT alinamalita afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT danielksmith afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT dylanfmmarple afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT ethomasdanielsen afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT sinekpetersen afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT jakoblhansen afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT kennethahalberg afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT kimfrewitz afattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT michaeljtexada fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT annefjørgensen fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT christianfchristensen fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT takashikoyama fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT alinamalita fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT danielksmith fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT dylanfmmarple fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT ethomasdanielsen fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT sinekpetersen fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT jakoblhansen fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT kennethahalberg fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion AT kimfrewitz fattissuesensorcouplesgrowthtooxygenavailabilitybyremotelycontrollinginsulinsecretion
_version_	1718382301683908608

A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion

Ejemplares similares