MiDAS-Meaningful Immunogenetic Data at Scale.

MiDAS-Meaningful Immunogenetic Data at Scale.

Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. However, association studies involving immunogenetic loci most commonly involve simple analyses of classical HLA allelic diversity, resulting in limi...

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Autores principales: Maciej Migdal, Dan Fu Ruan, William F Forrest, Amir Horowitz, Christian Hammer
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/eb1deaaeb2a8463897dfba4588dedffb
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spelling oai:doaj.org-article:eb1deaaeb2a8463897dfba4588dedffb2021-12-02T19:57:25ZMiDAS-Meaningful Immunogenetic Data at Scale.1553-734X1553-735810.1371/journal.pcbi.1009131https://doaj.org/article/eb1deaaeb2a8463897dfba4588dedffb2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009131https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. However, association studies involving immunogenetic loci most commonly involve simple analyses of classical HLA allelic diversity, resulting in limitations regarding the interpretability and reproducibility of results. We here present MiDAS, a comprehensive R package for immunogenetic data transformation and statistical analysis. MiDAS recodes input data in the form of HLA alleles and KIR types into biologically meaningful variables, allowing HLA amino acid fine mapping, analyses of HLA evolutionary divergence as well as experimentally validated HLA-KIR interactions. Further, MiDAS enables comprehensive statistical association analysis workflows with phenotypes of diverse measurement scales. MiDAS thus closes the gap between the inference of immunogenetic variation and its efficient utilization to make relevant discoveries related to immune and disease biology. It is freely available under a MIT license.Maciej MigdalDan Fu RuanWilliam F ForrestAmir HorowitzChristian HammerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009131 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Maciej Migdal
Dan Fu Ruan
William F Forrest
Amir Horowitz
Christian Hammer
MiDAS-Meaningful Immunogenetic Data at Scale.
description Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. However, association studies involving immunogenetic loci most commonly involve simple analyses of classical HLA allelic diversity, resulting in limitations regarding the interpretability and reproducibility of results. We here present MiDAS, a comprehensive R package for immunogenetic data transformation and statistical analysis. MiDAS recodes input data in the form of HLA alleles and KIR types into biologically meaningful variables, allowing HLA amino acid fine mapping, analyses of HLA evolutionary divergence as well as experimentally validated HLA-KIR interactions. Further, MiDAS enables comprehensive statistical association analysis workflows with phenotypes of diverse measurement scales. MiDAS thus closes the gap between the inference of immunogenetic variation and its efficient utilization to make relevant discoveries related to immune and disease biology. It is freely available under a MIT license.
format article
author Maciej Migdal
Dan Fu Ruan
William F Forrest
Amir Horowitz
Christian Hammer
author_facet Maciej Migdal
Dan Fu Ruan
William F Forrest
Amir Horowitz
Christian Hammer
author_sort Maciej Migdal
title MiDAS-Meaningful Immunogenetic Data at Scale.
title_short MiDAS-Meaningful Immunogenetic Data at Scale.
title_full MiDAS-Meaningful Immunogenetic Data at Scale.
title_fullStr MiDAS-Meaningful Immunogenetic Data at Scale.
title_full_unstemmed MiDAS-Meaningful Immunogenetic Data at Scale.
title_sort midas-meaningful immunogenetic data at scale.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/eb1deaaeb2a8463897dfba4588dedffb
work_keys_str_mv AT maciejmigdal midasmeaningfulimmunogeneticdataatscale
AT danfuruan midasmeaningfulimmunogeneticdataatscale
AT williamfforrest midasmeaningfulimmunogeneticdataatscale
AT amirhorowitz midasmeaningfulimmunogeneticdataatscale
AT christianhammer midasmeaningfulimmunogeneticdataatscale
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