Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
As an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented...
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2021
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oai:doaj.org-article:eb1df236cb1e4d7ea9c4a40e02ca16ff2021-11-10T06:39:17ZCase Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation2296-858X10.3389/fmed.2021.762763https://doaj.org/article/eb1df236cb1e4d7ea9c4a40e02ca16ff2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.762763/fullhttps://doaj.org/toc/2296-858XAs an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented with severe headache and slight fever after undergoing transnasal endoscopic repair of cerebrospinal fluid rhinorrhea. Chronic sinusitis and suspicious intracranial fungal lesions were observed on enhanced magnetic resonance imaging (MRI). Both culture and metagenomic next-generation sequencing of her cerebrospinal fluid were positive for Sarocladium strictum. After local debridement, treatment with amphotericin B plus voriconazole and Ommaya reservoir implantation, the patient improved significantly. Unfortunately, her symptoms worsened again despite plenty of antifungal therapy for a month.Yue CuiJiali MengJing ZhangLin WangHaihan YanHan XiaJingrong CaoLiyong WuFrontiers Media S.A.articlemeningoencephalitisSarocladium strictummetagenomic next-generation sequencingfungal infectiontreatmentMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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meningoencephalitis Sarocladium strictum metagenomic next-generation sequencing fungal infection treatment Medicine (General) R5-920 |
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meningoencephalitis Sarocladium strictum metagenomic next-generation sequencing fungal infection treatment Medicine (General) R5-920 Yue Cui Jiali Meng Jing Zhang Lin Wang Haihan Yan Han Xia Jingrong Cao Liyong Wu Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation |
| description |
As an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented with severe headache and slight fever after undergoing transnasal endoscopic repair of cerebrospinal fluid rhinorrhea. Chronic sinusitis and suspicious intracranial fungal lesions were observed on enhanced magnetic resonance imaging (MRI). Both culture and metagenomic next-generation sequencing of her cerebrospinal fluid were positive for Sarocladium strictum. After local debridement, treatment with amphotericin B plus voriconazole and Ommaya reservoir implantation, the patient improved significantly. Unfortunately, her symptoms worsened again despite plenty of antifungal therapy for a month. |
| format |
article |
| author |
Yue Cui Jiali Meng Jing Zhang Lin Wang Haihan Yan Han Xia Jingrong Cao Liyong Wu |
| author_facet |
Yue Cui Jiali Meng Jing Zhang Lin Wang Haihan Yan Han Xia Jingrong Cao Liyong Wu |
| author_sort |
Yue Cui |
| title |
Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation |
| title_short |
Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation |
| title_full |
Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation |
| title_fullStr |
Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation |
| title_full_unstemmed |
Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation |
| title_sort |
case report: a case of sarocladium strictum meningoencephalitis in an immunocompetent patient after invasive operation |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/eb1df236cb1e4d7ea9c4a40e02ca16ff |
| work_keys_str_mv |
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