Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation

As an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented...

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Autores principales:	Yue Cui, Jiali Meng, Jing Zhang, Lin Wang, Haihan Yan, Han Xia, Jingrong Cao, Liyong Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	meningoencephalitis Sarocladium strictum metagenomic next-generation sequencing fungal infection treatment Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eb1df236cb1e4d7ea9c4a40e02ca16ff
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spelling	oai:doaj.org-article:eb1df236cb1e4d7ea9c4a40e02ca16ff2021-11-10T06:39:17ZCase Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation2296-858X10.3389/fmed.2021.762763https://doaj.org/article/eb1df236cb1e4d7ea9c4a40e02ca16ff2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.762763/fullhttps://doaj.org/toc/2296-858XAs an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented with severe headache and slight fever after undergoing transnasal endoscopic repair of cerebrospinal fluid rhinorrhea. Chronic sinusitis and suspicious intracranial fungal lesions were observed on enhanced magnetic resonance imaging (MRI). Both culture and metagenomic next-generation sequencing of her cerebrospinal fluid were positive for Sarocladium strictum. After local debridement, treatment with amphotericin B plus voriconazole and Ommaya reservoir implantation, the patient improved significantly. Unfortunately, her symptoms worsened again despite plenty of antifungal therapy for a month.Yue CuiJiali MengJing ZhangLin WangHaihan YanHan XiaJingrong CaoLiyong WuFrontiers Media S.A.articlemeningoencephalitisSarocladium strictummetagenomic next-generation sequencingfungal infectiontreatmentMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	meningoencephalitis Sarocladium strictum metagenomic next-generation sequencing fungal infection treatment Medicine (General) R5-920
spellingShingle	meningoencephalitis Sarocladium strictum metagenomic next-generation sequencing fungal infection treatment Medicine (General) R5-920 Yue Cui Jiali Meng Jing Zhang Lin Wang Haihan Yan Han Xia Jingrong Cao Liyong Wu Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
description	As an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented with severe headache and slight fever after undergoing transnasal endoscopic repair of cerebrospinal fluid rhinorrhea. Chronic sinusitis and suspicious intracranial fungal lesions were observed on enhanced magnetic resonance imaging (MRI). Both culture and metagenomic next-generation sequencing of her cerebrospinal fluid were positive for Sarocladium strictum. After local debridement, treatment with amphotericin B plus voriconazole and Ommaya reservoir implantation, the patient improved significantly. Unfortunately, her symptoms worsened again despite plenty of antifungal therapy for a month.
format	article
author	Yue Cui Jiali Meng Jing Zhang Lin Wang Haihan Yan Han Xia Jingrong Cao Liyong Wu
author_facet	Yue Cui Jiali Meng Jing Zhang Lin Wang Haihan Yan Han Xia Jingrong Cao Liyong Wu
author_sort	Yue Cui
title	Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
title_short	Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
title_full	Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
title_fullStr	Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
title_full_unstemmed	Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
title_sort	case report: a case of sarocladium strictum meningoencephalitis in an immunocompetent patient after invasive operation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/eb1df236cb1e4d7ea9c4a40e02ca16ff
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Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation

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