Activation of ERAD pathway by human hepatitis B virus modulates viral and subviral particle production.

Hepatitis B virus (HBV) belongs to the Hepadnaviridae family of enveloped DNA viruses. It was previously shown that HBV can induce endoplasmic reticulum (ER) stress and activate the IRE1-XBP1 pathway of the unfolded protein response (UPR), through the expression of the viral regulatory protein X (HB...

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Autores principales: Catalin Lazar, Alina Macovei, Stefana Petrescu, Norica Branza-Nichita
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/eb1f9ce9004744e6b3898e8de911feb6
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