DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

SWI/SNF genes are commonly found to be mutated in different cancers. Here the authors report that the remodelers BRM and BRG1 are necessary for efficient nucleotide excision repair by promoting the expression of TFIIH subunit GTF2H1.

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Autores principales: Cristina Ribeiro-Silva, Özge Z. Aydin, Raquel Mesquita-Ribeiro, Jana Slyskova, Angela Helfricht, Jurgen A. Marteijn, Jan H. J. Hoeijmakers, Hannes Lans, Wim Vermeulen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/eb220f4c08794f88ad5354ea35208f77
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