The structure of gangliosides hides a code for determining neuronal functions

Gangliosides are particularly abundant in the central nervous system, where they are mainly associated with the synaptic membranes. Their structure underlies a specific role in determining several cell physiological processes of the nervous system. The high number of different gangliosides available...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giulia Lunghi, Maria Fazzari, Erika Di Biase, Laura Mauri, Elena Chiricozzi, Sandro Sonnino
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	ceramide structure ganglioside–protein interactions gangliosides neuronal functions oligosaccharide structure plasma membrane Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/eb22c8b319e8439896d7dc9d57e2ea93
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb22c8b319e8439896d7dc9d57e2ea93
record_format	dspace
spelling	oai:doaj.org-article:eb22c8b319e8439896d7dc9d57e2ea932021-12-01T13:36:12ZThe structure of gangliosides hides a code for determining neuronal functions2211-546310.1002/2211-5463.13197https://doaj.org/article/eb22c8b319e8439896d7dc9d57e2ea932021-12-01T00:00:00Zhttps://doi.org/10.1002/2211-5463.13197https://doaj.org/toc/2211-5463Gangliosides are particularly abundant in the central nervous system, where they are mainly associated with the synaptic membranes. Their structure underlies a specific role in determining several cell physiological processes of the nervous system. The high number of different gangliosides available in nature suggests that their structure, related to both the hydrophobic and hydrophilic portion of the molecule, defines a code, although not completely understood, that through hydrophobic interactions and hydrogen bonds allows the transduction of signals starting at the plasma membranes. In this short review, we describe some structural aspects responsible for the role played by gangliosides in maintaining and determining neuronal functions.Giulia LunghiMaria FazzariErika Di BiaseLaura MauriElena ChiricozziSandro SonninoWileyarticleceramide structureganglioside–protein interactionsgangliosidesneuronal functionsoligosaccharide structureplasma membraneBiology (General)QH301-705.5ENFEBS Open Bio, Vol 11, Iss 12, Pp 3193-3200 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ceramide structure ganglioside–protein interactions gangliosides neuronal functions oligosaccharide structure plasma membrane Biology (General) QH301-705.5
spellingShingle	ceramide structure ganglioside–protein interactions gangliosides neuronal functions oligosaccharide structure plasma membrane Biology (General) QH301-705.5 Giulia Lunghi Maria Fazzari Erika Di Biase Laura Mauri Elena Chiricozzi Sandro Sonnino The structure of gangliosides hides a code for determining neuronal functions
description	Gangliosides are particularly abundant in the central nervous system, where they are mainly associated with the synaptic membranes. Their structure underlies a specific role in determining several cell physiological processes of the nervous system. The high number of different gangliosides available in nature suggests that their structure, related to both the hydrophobic and hydrophilic portion of the molecule, defines a code, although not completely understood, that through hydrophobic interactions and hydrogen bonds allows the transduction of signals starting at the plasma membranes. In this short review, we describe some structural aspects responsible for the role played by gangliosides in maintaining and determining neuronal functions.
format	article
author	Giulia Lunghi Maria Fazzari Erika Di Biase Laura Mauri Elena Chiricozzi Sandro Sonnino
author_facet	Giulia Lunghi Maria Fazzari Erika Di Biase Laura Mauri Elena Chiricozzi Sandro Sonnino
author_sort	Giulia Lunghi
title	The structure of gangliosides hides a code for determining neuronal functions
title_short	The structure of gangliosides hides a code for determining neuronal functions
title_full	The structure of gangliosides hides a code for determining neuronal functions
title_fullStr	The structure of gangliosides hides a code for determining neuronal functions
title_full_unstemmed	The structure of gangliosides hides a code for determining neuronal functions
title_sort	structure of gangliosides hides a code for determining neuronal functions
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/eb22c8b319e8439896d7dc9d57e2ea93
work_keys_str_mv	AT giulialunghi thestructureofgangliosideshidesacodefordeterminingneuronalfunctions AT mariafazzari thestructureofgangliosideshidesacodefordeterminingneuronalfunctions AT erikadibiase thestructureofgangliosideshidesacodefordeterminingneuronalfunctions AT lauramauri thestructureofgangliosideshidesacodefordeterminingneuronalfunctions AT elenachiricozzi thestructureofgangliosideshidesacodefordeterminingneuronalfunctions AT sandrosonnino thestructureofgangliosideshidesacodefordeterminingneuronalfunctions AT giulialunghi structureofgangliosideshidesacodefordeterminingneuronalfunctions AT mariafazzari structureofgangliosideshidesacodefordeterminingneuronalfunctions AT erikadibiase structureofgangliosideshidesacodefordeterminingneuronalfunctions AT lauramauri structureofgangliosideshidesacodefordeterminingneuronalfunctions AT elenachiricozzi structureofgangliosideshidesacodefordeterminingneuronalfunctions AT sandrosonnino structureofgangliosideshidesacodefordeterminingneuronalfunctions
_version_	1718405148853665792

The structure of gangliosides hides a code for determining neuronal functions

Ejemplares similares